Special Issue on Theoretical Chemistry/Chemical Dynamics

cover

This month’s issue of the Journal of Chemical Sciences honours Professor Charusita Chakravarty, who has made immeasurable contributions to theoretical chemistry and chemical dynamics. The editors Biman Bagchi (FASc, FNA, FTWAS; Indian Institute of Science, Bangalore, India), David Clary (FRS; Oxford University, Oxford, UK) and N Sathyamurthy (FASc, FNA, FTWAS; Indian Institute of Science Education and Research, Mohali, India) have put together a 29 articles on theoretical physical chemistry that are a fitting tribute to the diversity of the problems she studied. The three-hundred-page issue begins with an introduction to Charusita Chakravarty’s remarkable career and contributions to science.

You can read the issue here: http://www.ias.ac.in/listing/articles/jcsc/129/07

 

The Ooty Radio Telescope Upgrade

JAA_March2017_Cover

 

Around half a century ago the Radio Astronomy Group at TIFR, under the leadership of Prof. Govind Swarup, embarked on an ambitious project to build a radio telescope at Ooty. This 530-m-long and 30-m-wide cylindrical parabolic reflector had a unique design that allowed it to track a source in the sky with a single rotation of the telescope along the long axis of the cylinder. In these four decades, several very significant scientific discoveries were made in observational cosmology, pulsars, recombination lines and the interstellar medium as well as the inner heliosphere. The Ooty Radio Telescope (ORT) continues to be in regular operation and is currently being used for space weather studies as well as pulsar observations.

The ORT is currently undergoing a major upgrade to its receiver chain, which will result in a new system called the Ooty Wide Field Array (OWFA). The OWFA is designed to function as a 264-element interferometric array, and to provide a significantly larger instantaneous bandwidth as well as field-of-view compared to the legacy ORT receiver system. In addition to significantly enhancing the capabilities for heliospheric studies, this upgrade is also expected to open other avenues of research particularly in the newly emerging areas of 21-cm intensity mapping and studies of transient radio sources. Articles in a Special Section of the March 2017 issue of the Journal of Astrophysics and Astronomy  (http://www.ias.ac.in/listing/articles/joaa/038/01) present the scientific motivation, design and expected capabilities of this upcoming instrument.

0001 0002

Of Prisms, Soap Bubbles and Drones: National Science Day at the Academy!!!

“I propose this evening to speak to you on a new kind of radiation or light emission from atoms and molecules.” These were the historic words of Sir Chandrasekhara Venkata Raman as he began his lecture to the South Indian Science Association in Bangalore on March 16, 1928.

Following this Raman proceeded to describe a discovery of the world renowned Raman Effect which changed the course of physics and won him the Noble Prize in 1930…the first Asian and Indian to receive the most coveted prize of science.

Countless men must have observed the blue color of the sea since ancient times…but it took the genius of C V Raman to decipher the natural law behind this seemingly simple phenomenon.

The childlike curiosity about simple things and the perseverance to find answers is what sets scientists like Raman apart from others.

And what is more, the discovery was made far away from the great centers of scientific research and by using simple equipment aboard a ship sailing in Mediterranean Sea from Europe to Kolkata.

The Raman Effect explores the scattering of light when it passes through a medium. This explains that the blue color of sea which is due to the scattering of sunlight by the water molecules – a phenomenon which is called molecular diffraction.

When light falls on a liquid or a solid medium, some of the beams pass through, but a small part of the light is deflected and scattered in different directions by the molecules of the medium.

How they are deflected and scattered depends on the properties of the molecules: Raman demonstrated that the wavelength of the scattered light is different from the wavelength of the original incident beam. This change in wavelength of the light beam on deflection by a medium is known as the Raman Effect. Put simply, by measuring the change in wavelength, one can determine the properties of the medium.

Identified as one of the fundamental principles of optical physics, the Raman Effect finds immense applications in today’s digitalized world as well. Researchers and experts working in the area of pharmaceuticals, material sciences, petroleum industry and other chemical industries regularly use a technique called modern spectrometry. This method uses the spectrum of the scattered light to understand the molecular structure and properties of the material under study.

Similarly, there are scanners used to detect drugs, explosives, hazardous chemicals and gases, and these are based on the Raman Effect. Raman lidar is used in atmospheric physics to measure the atmospheric extinction coefficient and the water vapour vertical distribution. This list is endless…

February 28th – which marks the announcement of this fundamental principle that changed the world  –  is now celebrated as National Science Day in India.

National Science Day is a countrywide science festival celebrating the need and contributions of science and technology. A day when the nation commemorates the genius of Sir C V Raman and celebrates the spirit of science through a plethora of activities ranging from seminars, debates, quiz competitions, exhibitions and lectures involving college and school students, teachers and researchers.

Organized by the National Council for Science & Technology Communication Programmes,  activities of this year focus on “Science and Technology for Specially Abled Persons”. When India has achieved self-sufficiency in Green Revolution and Space technology, it is time to look inwards and address the needs of the specially abled. After all, tapping their potentials is integral to the overall development and progress of a civil society.

National Science Day at the Academy

????????????????????????????????????

The Indian Academy of Sciences every year looks forward to the National Science Day – a day that commemorates the scientific contributions of its Founder, a day to thank the entire scientific fraternity for all their contributions, and a day to introspect all that the Academy has been doing and aims to do, towards the promotion of science and scientific temper.

While various research institutes and colleges celebrate the national science day in their own unique ways across the nation, the Indian Academy of Sciences hosts an exclusive National Science Day event for students.

This year, school students from various parts of Bangalore visited to renowned Sir C V Raman Museum located in the Raman Research Institute.  The museum houses Raman’s prized collection of gems, crystals, minerals, and rock specimens from all over the world.  Worthy of special mention is the dark room of the museum where rock samples kept under UV light exhibit the phenomenon of ‘fluorescence’ – a rare sight which never fails to extract gasps of surprise and excitement from onlookers!!! Needless to say, curious students took multiple turns to see the wonder!

????????????????????????????????????

????????????????????????????????????

Raman was a strong believer of learning from experimenting and observing. Bringing the same spirit of experimentation and observation to the students was the ‘Hands-on Session’, by the Agasthya Foundation. The session focused on ingeniously designed yet simple set-ups and experiments to learn the natural principles that govern everyday life, such as friction, energy conversion, etc.

????????????????????????????????????

????????????????????????????????????

The occasion also saw the screening of the inspiring documentary on Raman’s life, and a drone flying session!!!!

While 2017 has dawned with new promises, and the world is looking eagerly towards many new technologies and novel applications of existing technologies, one much-anticipated technology is the drones. While the trend is already in motion, coming years are likely to see large-scale use of drones to deliver specialized services ranging from healthcare in remote areas and search-and-rescue operations to security and surveillance and even scientific data collection. To give students a flavor of the future, scholars from the Aerospace Engineering Department of IISc demonstrated their drone technology while describing their mechanisms and applications.

????????????????????????????????????

Now a question to the readers …

What is the relation between the Sydney Cricket Stadium and soap bubbles?

Well, it has nothing to do with drones; rather with energy minimization. This was demonstrated in the Science Day Talk by Shri H R Madhusudan, Jawaharlal Nehru Planetarium. It was  novel information for the students (in fact, even to most of the organizers as well) that the Sydney Cricket Stadium has been modelled on soap bubbles. The talk explored the concepts of isoperimetric problems – how circles with the same perimeter of a square will have larger area, and how such shapes in nature are optimized for energy minimization.  And of course the fascinating principle of same surface area, more volume was demonstrated through honeycombs!!!

As the sun sets on another National Science Day, let us acknowledge the contributions of the scientific fraternity at large and understand that if applied wisely, science and technology has immense power to transform the world.

Let us all strive towards leveraging this power to drive innovations that will make the world a better place to live in.

Science with the Square Kilometre Array: An Indian Perspective — A Special Issue of the Journal of Astrophysics and Astronomy

cover

The Square Kilometre Array (SKA) is one of the most prominent and ambitious of the next-generation radio astronomy facilities. It is so large that planning, designing and building SKA requires the international collaborations of ten countries, India being one of them. The first phase, SKA1, is in the design phase, and is expected to be operational by 2022.  Indian scientists are looking to enhance their scientific contribution to SKA, and also to build a base of astronomers that will be prepared to use the facility when it is ready.  The science initiatives in different areas are coordinated by the SKA India Science Working Groups (SWGs). The Indian SWG is instrumental in creating awareness related to the SKA within the Indian scientists by organizing talks, workshops, meetings, etc.

The goals for SKA1 cover a wide range of research areas starting from understanding the formation of stars using hyperfine transition of neutral hydrogen, to testing Einstein’s theory of general relativity using pulsars, to detailed understanding of some of the early phases in the life of the Universe. For example, SKA, with its unprecedented sensitivity and angular resolution, is expected to play a significant role in shaping our understanding of the star and planet formation from the molecular gas residing in the interstellar medium. The study of fast transients, e.g. Fast Radio Bursts, is likely to be a significant area of research with SKA because of its wide field-of-view and high sensitivity. It is expected that the SKA will be able to reveal a few hundred to thousand new radio haloes, relics and mini-haloes, thus providing a comprehensive catalogue for studying the origin of synchrotron radiation from these sources.

The international community is busy developing the so-called ‘Key Science Projects’ (KSPs), i.e. large scale collaborative projects addressing key scientific questions. Indian astronomers, too, are looking to build up their science cases so that they are in a position to play significant roles in the appropriate KSPs of interest. The first task along these lines was to prepare a set of articles highlighting the science areas which Indian scientists are interested in, and also to provide initial plans for what they would want to do with the SKA. Various scientists have been working on preparing these science articles for quite some time now, and this Special Issue of the Journal of Astrophysics and Astronomy is essentially the collection of all such articles. As one will see, the issue contains articles covering a wide range of science areas, almost all areas that are being explored by the SKA international community.  It is hoped that the present set of articles will provide a clear direction, both to the international as well as the Indian community, regarding the SKA-related science areas of current interest within India. It is also hoped that these articles will enthuse more astronomers to get involved with SKA, thus allowing the community to explore subjects beyond what has been covered in this issue. One can access the full articles here.

The 82nd Annual Meeting Lectures

The three-day 82nd Annual Meeting of the Indian Academy of Sciences, hosted by the Indian Institute of Science Education and Research, Bhopal, saw enthusiastic participation of members of the scientific and teaching community across the nation, with 91 Fellows and Associates of the Academy and 41 invited teachers attending the event.

­­­­­­The event began with the Presidential Address by Ram Ramaswamy (JNU, New Delhi), who spoke on ‘Chimeras: A spontaneous emergence of dynamical disorder’. Chimeras are the spontaneous emergence of a dynamic state with a mix of order and disorder. He spoke of his work on the physical and mathematical models for Chimeras in various systems, and the significance of Chimeras, particularly in biological processes such as uni-hemispheric sleep and ventricular fibrillation.

 

Ramaswamy

A special attraction of the first day of the meeting was the launch of CNR Rao’s book A Life in Science, published by Penguin India.  The book captures his long academic journey spanning 65 years and the trials and tribulations of a career in Science.  Rao mentions, in his book, several of his heroes in Science and how they have been a constant source of inspiration to him. He hopes the book will make Science as dear to the reader as it is to him.  BookRelease

A public lecture by CNR Rao on “How India Can be a World Leader in Science” followed. He spoke of how Science was receiving insufficient funding in India, which is one of the reasons why India’s contribution was fairly small. He advised students to choose good problems to work on. He said that the mindset of Indian society should change to one which places the highest value on science and education. He regaled the students of IISER Bhopal in a jam-packed auditorium with stories of Raman and Faraday, who despite adversities changed the face of science.

CNRRao_PublicLecture

 

****

In this series of Inaugural Lectures by the newly elected Fellows and Associates of the Academy, the first session began with a presentation by Arun Chattopadhyay (IIT, Guwahati), who spoke on an interesting new study that deals with complexation reaction on the surface of the quantum dot. The chemical reaction between the labile surface metal ion and an external organic ligand results in the formation of inorganic complexes on the quantum dot which not only alters the property of the quantum dot but also confers additional properties. This finds potential applications in chemical catalysis, light-emitting devices, medical imaging, solar cells, lasers and electronic devices.

Sanjib K Agarwalla (IOP, Bhubaneswar) discussed the three-flavour oscillation picture of neutrinos in light of the recent discovery of the smallest lepton mixing angle.  He also spoke of the projects to be handled by the India-based Neutrino Observatory.

Autoimmune diseases have considerably increased globally, and treatments using non-steroidal anti-inflammatory drugs, corticosteroids, disease-modifying antirheumatic drugs, and immunosuppressive agents are associated with limitations and side effects.  Javed N Agrewala’s (IMTECH, Chandigarh) group has verified the role of Caerulomycin A – a bacterial compound with antifungal and antibiotic properties – as a new drug to cure arthritis. Using animal models, they found that CaeA restrains arthritis symptoms by inducing the generation of Tregs and suppressing pro-inflammatory factors. They have patented their technology.

Starting with some of the classical examples of special values of L-functions, A Raghuram (IISER, Pune) conveyed the grandeur of this subject that draws upon several different areas of modern mathematics such as representation theory, algebraic and differential geometry, and harmonic analysis.

******

Walter Kohn Memorial Symposium

Commemorating the contributions of Noble Laureate Walter Kohn, whose work has revolutionized the understanding of electronic properties of materials, a special ‘Walter Kohn Memorial Symposium’ was conducted on the first day of the meeting.

HR Krishnamurthy (IISc, Bengaluru) chaired the session and presented a brief life timeline of Noble Laureate Walter Kohn.

Walter_Kohn_HRK

TV Ramakrishnan (BHU, Varanasi) traced the history and origin of the field of condensed matter physics and the crucial role that Walter Kohn played in the evolution of the field from obscurity to present prominence. Presenting an overview of the work by various researchers, Ramakrishnan highlighted the contributions of Walter Kohn in various aspects of electron theory of solids.

TVRamakrishnan

Tracing the history of density functional theory which arose from the single-particle electron density idea proposed by Walter Kohn, Swapan K Ghosh (BARC, Mumbai) discussed how, despite the differences in the nature of the density variables used in various DFT-based descriptions, the corresponding theoretical frameworks, share a unified structure. Ghosh elaborated on some of the developments and applications of DFT in diverse areas of chemistry and physics.

SwapanKGhosh_2

Tanusri Saha-Dasgupta (SNBNCBS, Kolkata) spoke about specific situations when the conventional DFT proves insufficient to predict the properties of materials. In such situations, DFT along with the Coulomb correlation, namely Hubbard U, and DFT along with Dynamical Mean Field Theory or DMFT are used. The effectiveness of these methods through applications in describing charge-ordered insulators and correlated metals was described.

TanusriSaha-Dasgupta

Umesh V Waghmare (JNCASR, Bengaluru) discussed his work on deciphering the interesting relationship between Wannier functions and non-Abelian Berry phases of Bloch electrons. The idea is centrally relevant to the nontrivial electronic topology exhibited by topological insulators, Weyl and Dirac semimetals.

UmeshVWaghmare

******

The first day concluded with a very inspiring talk by renowned water conservationist and Stockholm Water Prize and  Magsaysay Awardee, Rajendra Singh, from Tarun Bharat Sangh.

Preferring to talk in Hindi, he spoke passionately about how traditional water management systems, now long forgotten, would effectively meet the rising demand for water of today. He spoke of his experiences in Rajasthan, where, by use of traditional methods, several rivers that had dried up were now perennial. The methods used were unique to each agro-ecological zone, thus ensuring sustainability the river. He appealed to scientists to use their technology in conjunction with indigenous knowledge systems to come up with strategies to ensure the rivers of India be saved and remain the life-giving forces they are. He concluded on an ominous note that if we did not act now to save our rivers, the world would see a water war soon.

RajendraSingh1

****

The second day began with a special lecture on Academic Ethics by Sunil Mukhi (IISER, Pune).  Based on the document on Scientific Values prepared under the aegis of the Academy, he spoke on what ethics means. He elaborated on the contents of the document, with special emphasis on how to conduct research ethically. He focussed on publication ethics, by providing various definitions of plagiarism. He talked about how to paraphrase without plagiarising. He ended his talk with actions publishers must take towards spotting plagiarised papers.

SunilMukhi

Continuing the series of Inaugural Lectures by Fellows and Associates of the Academy, Pradyut Ghosh (IACS, Kolkata) spoke on his work on anion recognition by synthetic receptors, which finds application in water purification processes and industrial and nuclear waste reprocessing.  A wide variety of receptors (ligands) containing different anion recognition elements with increasing complexities have been developed by the speaker’s team.  Their recent work deals with (i) selective sensing of phosphates; (ii) separation of hydrated metal sulphates/potassium bromide; and (iii) halogen-bonding-assisted bromide removal.

Starting with Shannon’s noisy channel coding theorem, Ankur A Kulkarni (IIT, Bombay) spoke about the open question about finite blocklength performance and the existing solutions.  His group used convex relaxations and linear programming duality to obtain lower bounds for problems in information theory, which has resolved open issues about the role of Shannon theory in stochastic decentralized control and a 60-year-old open combinatorial problem posed by Levenshtein for the deletion channel.

Some of the most energetic events in the Universe are the explosive transients – gamma-ray burst sources (GRBs), supernovae and novae. GC Anupama (IIA, Bengaluru) spoke on the observational properties of these sources and mentioned the facilities that will be coming up in the next decade to observe these phenomena: the Large Synoptic Survey Telescope (LSST) and the Giant Segmented Large Telescopes.

Cellular stress response is a general term referring to a wide range of molecular changes that cells undergo in response to environmental stressors, including extremes of temperature, exposure to toxins, and mechanical damage. S Ganesh (IIT, Kanpur) spoke of his group’s finding that Sat3 transcripts are required for the full protection from heat-shock-induced cell death, and that the loss of these transcripts leads to a partial relief of heat-shock-induced transcriptional repression.

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), afflicts about one-third of the world population. KN Balaji (IISc, Bengaluru) spoke of the ability of Mtb to strategize host miRNAs for inhibition of autophagy and to plant host epigenetic modifiers for generation of foamy macrophages, so as to create a haven in the hostile environment offered by the host.

Charge is transferred between the atoms in a Quantum Dot (QD). The transferred charge resides in a quantum confined state. The Quantum Dot electronic structure can be approximated remarkably well as a Spherical Particle in a Box problem. The formation mechanisms and the reasons behind the emergence of atom-like characteristics in QDs were described by Anshu Pandey (IISc, Bengaluru). QDs react the same way as atoms and their “chemistry” allows the synthesis of stoichiometric compounds, he added. Various examples of chemical reactions between QDs and also the energetics of such reactions were described.

***

Symposium on ‘Our Second Genome’

The recent decades have seen unprecedented developments in the field of biological sciences. Armed with novel tools and next-generation sequencing technologies biologists are delving deep into the molecular realms of life. The buzzword in this context has been the microbiome. Celebrating these achievements of biological sciences and the focusing on the science of microbiome a special symposium on “Our Second Genome” was organised on the second day of the meeting.

Tracing the origin and history of the discipline of microbiome Partha P Majumder (NIBMG, Kolkata) introduced the audience to the emerging field of microbiome also highlighted the microbiome diversity in human systems.  He discoursed the need of understanding the relationship of “our second genome” with that of our own genome and gave an overall view of the novel insights on microbiome especially in the context of human health and well-being.

ParthaPMajumder

The gut microbiome is related to many human disorders including diabetes and cardiovascular disorders. They are even known to play a major role in antibiotic resistance and bioavailability of drugs. Sharmila S Mande (TCS, Pune) discussed the composition and functions of the microbiome of the human gut and the challenges in estimating the taxa diversity, identity and genes of gut microbes.  An end-to-end metagenomics platform is being developed by her team to analyse the microbiome data generated from various sequencing platforms. Their study will give important clues to the differences in gut microbiome across age, environment, and population, opening up novel avenues of translational and personalized medicine.

SharmilaSMande

Vineet K Sharma (IISER, Bhopal) discussed his metagenomics studies of healthy and diseased individuals in Indian population. The links between gut flora and disorders such as malnourishment, tuberculosis, and mental disorders highlight the need to develop robust platforms to analyse microbiome. Novel metabolic capabilities of human gut flora involved in the metabolism of different food substrates and xenobiotics were revealed during the speaker’s analyses.

VineetKSharma

Microbiome is not restricted to the gut. In fact, microbes are dominant in skin, the largest organ of the human body, and have direct implications for skin health. Souvik Mukherjee (NIBMG, Kolkata) focused on his work on the characterisation of facial skin microbiome in the Indian population of Dravidian descent.

SouvikMukherjee

Shekhar C Mande (NCCS, Pune), proposing a large-scale study on the Indian population and microbiota highlighted the need of “The Indian human microbiome initiative”. The large-scale project is conceptualized to address some of the fundamental questions related to the effect of microbiota on human health, especially in the context of the Indian population. Mande outlined the study design and coordination plan for the collaborative initiative which aims to cover 90 communities and 20,000 subjects across various geographic regions with the objective of mapping of microbiota five different body sites. 

ShekharCMande

 

******

 

The second day of the meeting ended with a public lecture by Ravi Korisettar from Dr VS Wakankar Archaeological Research Institute, who took the audience on a virtual geological tour with his talk on the importance of the Vindhya basin in the prehistory of the Indian subcontinent. The speaker traced the journey of early human beings (Homo erectus) from Africa to the Indian subcontinent. Highlighting the importance of Vindhya basin in studying the pattern of dispersal of ancient humans in India, he presented the evidence gathered from various Paleolithic sites in the Vindhya basin which help researchers understand the migration and habitation pattern of early humans in India and the factors that aided this.

RaviKorisettar1

****

The third day’s Inaugural Lectures began with Krishna P Kaliappan (IIT, Mumbai). He outlined the novel procedures developed by his team to synthesize complex compounds such as vinigrol, taxol, and N-heterocyclic amides through a minimum number of steps to achieve ideal synthesis. The molecules are considered crucial because of their biological activity and the newly developed methods overcome many drawbacks of the conventional synthesis techniques of such molecules.

Appa Rao Podile  (UoH, Hyderabad) shared his research, elaborating on the process of plant immunity triggered upon infection by pathogens and the progress made towards understanding this process. A major player in such immunity involves chitooligosaccharides released during plant-fungal interactions which elicit plant defence. The speaker discussed his work on identifying enzymes like chitinase(s), which help in the chemical process of transglycosylation and generation of long-chain chitooligosaccharides which triggers immunity.

N Ravishankar (IISc, Bengaluru) discussed the simple wet chemical method for growing ultrathin gold nanowires in a phase developed by his team along with detailed description of the mechanism of gold nanowires using electron microscopy as the principal supporting tool.  The fascinating insulating behaviour of gold nanowires corresponding to decrease in resistivity as a function of the temperature of measurement was presented.  The gold nanowires are likely to find potential applications in developing sensors and aiding catalysis

In the recent years, CRISPR-Cas technology has emerged as one of the most robust molecular biology techniques ever developed. B Anand (IIT, Guwahati) explored how bacteria integrate phage fragments to acquire immunity in the CRISPAR-Cas pathway.  His work on how the pathway involving various complexes confers heritable adaptive immunity to bacteria serving as immunological memory was discussed.

Analytic functions are extremely important in physics, chemistry, electrical engineering, etc. Tirthankar Bhattachrya (IISc, Bengaluru) explained what analytic functions were with several illustrations such as the disc and bidisk formulae, and the transfer function used in input-output systems by engineers.

Low-temperature scanning tunneling spectroscopy has emerged as one of the most powerful tools to study electronic properties of solids at low temperature, with unsurpassed spatial and energy resolution.  Pratap Raychaudhuri (TIFR, Mumbai) spoke of the basics of this technique and the low-temperature scanning tunneling microscope developed in TIFR.

Evolution and extinction of life are tied intimately to the seawater chemistry. Reconstruction of the temporal changes in the redox state of seawater is crucial in understanding the trace elemental inventory of oceans and its influence on the biosphere. G R Tripathy (IISER, Pune) spoke of his work on the 187Re-187Os systematic of organic-rich marine sediments, which uniquely provides reliable information for their depositional age and past marine chemistry.

The 82nd Annual Meeting concluded with a special lecture on ‘Experimental ecology and evolution in the laboratory’ by Amitabh Joshi (JNCASR, Bengaluru). The opportunities offered by experimental ecology and evolution studies in laboratory settings aid the study of evolutionary and ecological mechanisms, which are otherwise not possible in the wild. What makes Drosophila the ideal biological model to answer questions at the interface of ecology and evolutionary biology was highlighted in his research on various aspects of heredity, development, and ecology of Drosophila populations. These studies illustrated how the evolutionary process is far more subtle and responsive to minor changes in ecology than often perceived.

AmitabhJoshi

***

The 82nd Annual Meeting

It is that time of the year again — time for the Academy’s Annual Meeting!  This year the City of Lakes will host the eighty-second annual meeting of the Academy from 4 to 6 November.

AM progposter prn 22oct2016-page-001

This year’s highlights are the symposia in honour of Prof. Walter Kohn and on “Our Second Genome”.

Walter Kohn played a prominent role in the evolution of condensed matter physics from obscurity to its present prominence. The talks in this symposium will range from Kohn’s contributions to the field, to the density functional theory (DFT) of Kohn, and beyond.

Only about 10% of cells associated with a human body are human cells; the remaining 90% are cells of microorganisms. This microbial community (called microbiome) is therefore expected to have huge influence on our health and well-being. The understanding of the relationship of “our second genome” with that of our own genome is just beginning to emerge. The effect of this second genome on human health will be discussed in several talks.

AM sympposter prn 22oct2016-page-001

The public lectures are always on timely topics, and what could be more relevant than Rajendra Singh’s talk on indigenous water management systems? Rajendra Singh is a well-known water conservationist from Alwar district, Rajasthan. He is known as the “waterman of India”. The Guardian named him among its list of “50 people who could save the planet”. He runs an NGO called Tarun Bharat Sangh (TBS), which was founded in 1975. TBS has been instrumental in fighting slow bureaucracy and mining lobbies, and has helped villagers take charge of water management in their semi-arid area close to Thar Desert, through the use of johad, rainwater storage tanks, check dams and other time-tested as well as path-breaking techniques. Starting from a single village in 1985, over the years TBS helped build over 8,600 johads and other water conservation structures to collect rainwater for the dry seasons, has brought water back to over 1,000 villages and revived five rivers in Rajasthan.

The other public lecture is by none other than historian and archaeologist, Ravindra Korisettar. The Indian subcontinent has witnessed two major phases of human expansion out of Africa during the Pleistocene (during the last 2 million years). Not only the timing of Homo sapiens expansion into the subcontinent but also the intra-subcontinental expansion needs to be placed in geo-environmental perspective to be able to arrive at definite picture of the role of regional geographical environments within the subcontinent that may have played a pivotal in the expansion process within and without the subcontinent. The Vindhya Basin preserves the highest density of Palaeolithic settlements as well as evidence for continuity of human occupation throughout the Pleistocene. He will focus on the nature of evidence from this region and also from the related regions to emphasise the need for multidisciplinary investigation at select sites while highlighting the achievements of Palaeolithic research and our understanding of cultural evolution during the Pleistocene.

Special lectures this time are on academic ethics in India and on  experimental ecology and evolution studies in laboratory settings.

AM lectposter prn 22oct2016-page-001

 

This year we have another special event: Dr CNR Roa’s book “A Life in Science”, published by Penguin India will be released on 4 Nov by Prof Ram Ramaswamy, President, IASc.

A Life in Science Invite side 1

Join us on 4–6 November 2016, at IISER Bhopal!
For a detailed programme card, click here: http://www.ias.ac.in/Events/Annual_Meetings/82nd_Annual_Meeting
For updates follow us on Twitter.

 

A new Masterclass eBook: Linear Algebra and Analysis

Math

The Indian Academy of Sciences has published a new eBook in the Masterclass series, titled ‘Linear Algebra and Analysis ’, directed primarily at students and teachers of the undergraduate level. The eBook is a compilation of ten pedagogical articles on the topic– eight of which are sourced from Resonance, the Journal of Science Education, and two additional articles authored by Professor Rajendra Bhatia.

The articles in the eBook are written in a style that makes them appealing to readers from diverse backgrounds, approaching the subject in a manner of instruction that is different from conventional textbooks. This allows readers to correctly perceive several crucial aspects of Linear Algebra and Analysis, enabling them to encounter problems in the field with clarity and confidence.

The eBook discusses the following topics

  • Contributions of William T Gowers
  • Contributions of David Hilbert
  • How Algebraic Geometry Solves an Old Matrix Problem
  • Orthogonalisation of Vectors
  • Triangularization of a Matrix
  • Eigenvalues of AB and BA
  • The Unexpected Appearance of Pi in Diverse Problems
  • The Logarithmic Mean
  • Convolutions
  • Vibrations and Eigenvalues

About the author:

Professor Rajendra Bhatia  of the Indian Statistical Institute has made vast contributions in the fields of mathematics. Earlier, he was at the Tata Institute and in the University of Bombay. He has held visiting positions at several universities, the first of these being at the University of California, Berkeley, in 1979, and the latest being at Shanghai University in 2015.

Professor Rajendra Bhatia is a master of exposition and hence, quite inevitably, the author of several books. It is, therefore, appropriate that a collection of his essays, which have previously been published in Resonance, now be made available in a convenient format for the benefit of anyone who wishes to the comprehend the subject in an elaborate, yet simplified, manner.

Get your copy of the eBook here.

Seismically susceptible regions in the western Himalaya identified by a team from IIT Roorkee

earthquake regions

The western Himalaya experiences a considerable number of earthquakes of varying magnitudes; the most well-known one being the 1905 Kangra earthquake. Different regions in the western Himalaya –comprising the states of Jammu & Kashmir, Himachal Pradesh and Uttarakhand –are known to exhibit varying degrees of seismicity.  Thus, in order to have a better disaster management system and for improved disaster mitigation, it becomes necessary to differentiate the seismically more-vulnerable regions from the less-vulnerable ones.

A group from the Department of Earthquake Engineering, IIT Roorkee, has identified seismically susceptible areas in the western Himalaya. Profs Mridula, Amita Sinvhal and Hans Raj Wason have shown that most of Himachal Pradesh and Uttarakhand and a few regions of Jammu & Kashmir, Punjab, Uttar Pradesh and Haryana are at the greatest risk. Most of Jammu & Kashmir was found to be only moderately susceptible, while the Indo-Gangetic plains appeared to be the least susceptible. Their findings have shown that several earthquake zones categorised in the ‘seismic zoning map’ by the Bureau of Indian Standards need to be reworked.

For this study, they used the technique of ‘pattern recognition’. Simply put, PR technique, is a form of machine learning that relies on various available tectonic and seismology data of the region. The data was sourced from seismic events that have occurred beginning from the year 1552. The data needed to be appropriately and accurately categorised based on a set of parameters (such as the magnitude of the earthquakes and various features of the earth’s landscape) and fed into the system. The PR technique can then predict future earthquakes based on the recognition of existing patterns.

“This study allowed us to identify and narrow down areas where most recent earthquakes are originating, and also where strong earthquakes may recur. These results can contribute to improving the characterisation of seismic sources for seismic hazard assessment,” the scientists state in their study.

The work is published in the Journal of Earth System Science in June 2016. Link here.

Special Issue On HIGGS PHYSICS In Pramana – Journal Of Physics

Higgs1

From the discovery of the Higgs Boson, to how supersymmetry solves the Naturalness Problem, to research on electroweak phase transitions and related phenomena such as cosmological baryogenesis, electroweak bubble dynamics, generation of gravitational waves, etc., the latest edition of Pramana – Journal of Physics covers, in a latitudinarian manner, a spectrum of discussions on the current standing of the field of particle physics.

As described in the preface of the journal’s special issue on Higgs Physics, the review articles seek to answer questions such as the following:

  • Is the discovery of the 125 GeV resonance at the LHC suggestive of a new physics beyond the Standard Model?
  • If the discovery was indeed that of a Higgs boson as described by the Standard Model, then what keeps it light and protected from large quantum corrections?
  • What do this discovery and its associated theoretical investigations tell us about other questions on symmetry breaking?
  • If the discovered particle is only approximately the SM Higgs, then is the electroweak breaking mechanism driven by an extended scalar sector? (This becomes relevant, especially when considering the purported excess in the γγ final state at 750 GeV).
  • Is new physics (at the few TeV scale), then, well-approximated by a simple two-Higgs doublet model or should we consider more elaborate structures such as the minimal supersymmetric SM?

In the pursuit of the solutions to these questions and their like, however, the September 2016 issue of Pramana raises other, rather compelling, ones. Access the full articles here.

Ayurgenomics – a new player in biomedical sciences.

Contemporary medical science has, until recent times, remained in perennial search of a single cause of a disease, be it physiological or molecular. Looking at the human body through a systems perspective is a relatively new approach in the field of biomedicine. Ayurveda, the Indian traditional medical system, on the other hand, has always looked at diseases as a holistic response of an individual to the environmental challenge.

The bane of Ayurveda, however, is that unlike the present day allopathic system it lacks documented records of experiments, research methodology, peer-reviewed studies, and population-based investigations, in the manner as seen today. There are only a few molecular correlates to back up this ancient system of healing – to connect it to our present understanding of human health. Well, that was so, at least until recently.

The situation now seems to be changing rather positively. In an article, recently published in the Journal of Genetics (Prasher et al., “Genomic insights into ayurvedic and western approaches to personalised medicine), Dr Mitali Mukerji and Dr. Bhavana Prasher, from CSIR-Institute of Genomics and Integrative Biology have described Ayurgenomics – an emerging field that integrates the science of genomics to investigate Ayurvedic concepts, drawing parallels between ‘Prakriti’ and ‘gene expression patterns’ in people. The paper argues that “recognition of the underlying systems biology has been effective in the translation of network medicine into clinical practice of Ayurveda for thousands of years”.

In the Ayurvedic system, people are classified on the basis of Prakriti, which basically characterises a person’s constitution, defined by the relative proportions of three basic elements, a.k.a. ‘three doshas’ or ‘Tridosha’. The three doshasVata (kinetic), Pitta (metabolic) and Kapha (potential) and their combinations Vata-Pitta, Pitta-Kapha, Vata-Kapha and Vata-Pitta-Kapha are the 7 classes of healthy physiological constitutions that, according to Ayurveda, any person can be categorised into. A person’s Prakriti, based on his inherent dosha, is responsible for the way he looks, his skin, hair, body type, physical-, mental-, metabolic- abilities, health, etc. Any disruption, in any of these basal states of Vata, Pitta and Kapha, leads to disease. Ayurvedic therapy, therefore, is directed towards the restitution of a balanced state of doshas, based on a person’s Prakriti.

While Ayurvedic concepts may sound abstract and unrealistic, the Ayurgenomics team at CSIR-IGIB, through their studies, has been able to identify unique molecular signatures for each individual. In an earlier study, the first of its kind, the authors sampled 96 healthy unrelated individuals – belonging to any of the three basic Prakriti types (Vata, Pitta or Kapha), in order to determine whether each class could be mapped to a unique molecular signature. The answer, following Genome-Wide Association Studies and various biochemical profiling analyses, was in the affirmative.

The study, reported in the Journal of Translational Medicine in 2008, revealed a number of genes that were differently expressed between the three Prakriti classes. More authentically, the list of genes included were those involved in core regulatory functions – ones known to impact multiple phenotypes and physiological processes. “Since the method of Prakriti phenotyping captures multiple seemingly unconnected systems, genetic variation underlying Prakriti could enable identification of hub genes that would have system-wide effects”, say the researchers in their article. Their studies provide proof of concept for the Ayurvedic principle of Tridoshas.

One of the genes identified in the study was ELGN1, whose product regulates the activity of a transcription factor, HIF1a, that is involved in allowing cells adapt to hypoxia. The EGLN1 product has multiple roles in the body, and dysregulation of this gene has been linked to diseases affecting various body systems. Genotypic variations responsible for variable expression of this gene can either assist recovery, like in the case of ischemia, or exacerbate the disease as observed in cancer. Based on their findings, the authors propose that this molecule could be a ‘molecular contributor to Tridosha’. Of course, this is only the beginning. Multiple studies are now being carried out whose results can be applied to the Ayurvedic concept of Trisutra (meaning: causes, symptoms and treatment of a disease), warranting further investigations along the same line.

The review article, co-authored by Dr Bhavana Prasher and Prof. Mitali Mukerji from CSIR-Institute of Genomics and Integrative Biology, New Delhi, and Prof. Greg Gibson from the Georgia Institute of Technology, Atlanta, can be freely accessed using the link provided here.