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Table of contents
Unravelling secrets of a sleeping microbe: The curious case of the TB pathogen
Slide 2
Tuberculosis Disease = Host + M. tb interaction
Magnitude of problem due to LTBI
The importance of knowing the nature of dormant organisms
Bacterial dormancy
Experimental models of dormancy
Slide 8
DevR-DevS/DosT signal transduction system
Interception points in the signalling cascade
Intercepting the DevR signalling pathway
Slide 12
Structure-based design of DevR inhibitor
A cell infection model of dormancy: an example of serendipity
Slide 15
Slide 16
Ascorbic acid rapidly scavenges O2 to induce dormancy
Implications and Opportunities
Acknowledgments
Slide 20