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Table of contents
Rational Development of Malaria Vaccines Chetan Chitnis ICGEB, New Delhi
Malaria Life Cycle – Points of Intervention
Red Cell Invasion by Malaria Parasites
Invasion Specificity of Plasmodium sp.
Erythrocyte Binding Proteins
Deletion of P. knowlesi a gene – no junction formation, no invasion
Erythrocyte Binding Proteins (EBPs)
Receptor-binding Domains of EBPs
Binding Site for PvDBP on DARC
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Hypothesis
Treatment Re-infection Study: Mugil, Papua New Guine
Study Design
Study Population
Slide 18
Anti-PvRII Blocking Abs are Associated with Delay in Time to Re-infection with P. vivax
Anti-PvRII Blocking Abs are Associated with Delay in Time to Re-infection with P. vivax but not P. falciparum
High Anti-PvRII Blocking Abs are Associated with Reduction in P. vivax Parasite Density
High Anti-PvRII Blocking Abs are Associated with Reduction in P. vivax Parasite Density but not P. falciparum Parasite Density
Anti-PvRII High Blocking Abs are Strain-transcending
Process Development to Produce Recombinant PvRII
Slide 25
Blocking Abs elicited by immunization with PvRII are strain transcending
Summary – Rationale for a Vaccine Based on PvRII
Development Path
Acknowledgements