M V Shirsat
Articles written in Proceedings – Section A
Volume 14 Issue 6 December 1941 pp 630-635
In the course of the attempts to study the effects of the different types of substituents in the molecule of 2-N1-sulphanilamidothiazole, the synthesis of a series of 2-N1-sulphanilamido-5-alkyl- and 2-N1-sulphanilamido-4-methyl-5-alkyl- thiazoles, wherein the alkyl group varies from ethyl to hexyl, have been effected and these compounds are described.
Volume 16 Issue 2 August 1942 pp 115-125
Sulphanilylguanidine condensed with ethyl acetoacetate and its α-alkyl derivatives to yield 2-sulphanilamido-4-methylpyrimidone and 2-sulphanilamido-4-methyl-5-alkylpyrimidones respectively. Experiments have been recorded which support these structures and a number of intermediate compounds are described. Ethyl formylacetate condensed with sulphanilyl-guanidine to furnish 2-sulphanilamidopyrimidone. Hydroxymethyleneacetone and hydroxymethylene ethylbutylketone failed to condense with sulphanilylguanidine to yield the corresponding pyrimidines in appreciable yields. Mesityl oxide, on the other hand, has yielded two products which are represented provisionally as the two possible pyrimidine derivatives (XIV) and (XV).
Volume 16 Issue 2 August 1942 pp 126-128
A number of carboxylic acid derivatives of 2-sulphanilamidothiazole with the acid grouping attached directly or through alkyl radicals to the thiazole ring at the positions 4 or 5, are described.
Volume 18 Issue 6 December 1943 pp 360-363
2-Aminothiazole condensed with acetsulphanilylchloride in aqueous solution or suspension in the presence of sodium bicarbonate, calcium carbonate or barium carbonate to yield 2-diacetsulphanilylamidothiazole m.p. 128–29°; the same product is also obtained by condensing 2-aminothiazole with two molecular equivalents of acetsulphanilylchloride in pyridine or by condensing 2-acetsulphanilamidothiazole with acetsulphanilylchloride in alkaline solution. This compound on boiling with alcohol isomerises into 2-acetsulphanilimido-3-sulphanilylthiazolone. These two products are hydrolysed by acid or alkali to sulphathiazole in good yield. A process of preparation of sulphathiazole is described.