Articles written in Proceedings – Section A
Volume 46 Issue 4 October 1957 pp 265-271
8-Methyl baicalein has been made (1) from 8-methyl chrysin by the preparation of the 6-aldehyde and subsequent Dakin’s reaction and (2) from C-methyl phloracetophenone dimethyl ether by steps involving persulphate oxidation and flavone ring closure. The isomeric 6-methyl compound has been obtained by the nuclear methylation of norwogonin and demethylation with aluminium chloride. The methyl ethers of the former undergo only demethylation when boiled with hydriodic acid whereas those of the latter undergo isomeric change besides demethylation.
Volume 50 Issue 3 September 1959 pp 192-195
In the case of nor-wogonin and 5:7:8-trihydroxy-2-methylchromone, Gattermann method is efficient in yielding the corresponding aldehydes, whereas with their 8-methyl ethers hexamine method works satisfactorily.