In the present investigation, machining performance of Ti6Al4V is studied under dry environment, pressurized air supply and distilled water based Minimum Quantity Lubrication (MQL). Machining (turning) performance is assessed in purview of cutting force (tangential component) magnitude, tool-tip temperature,width of tool flank wear progression, morphology of evolved chips and severity of vibrations at varied cutting speeds as well as cooling media. Characteristic features of spatial temperature distribution profile (at the vicinity of tool-tip) as influenced by varied cooling media are studied with the help of thermographs of the cutting zone. Mechanisms of cutting tool wear are studied as well. It is experienced that amongst three cutting environments tested, application of water-MQL is beneficial for machining of Ti6Al4V at low cutting speed. Severity of vibrations gets 50.39% reduced during machining under water-MQL than dry condition. Consequently, as compared to dry machining, water-MQL causes 79% reduced tool flank wear and 82% reduced crater wear at low cutting speed. Under water-MQL, reduced tool-tip temperature (66% reduced than dry condition) suppresses severity of tool wear. In comparison with high cutting speed, performance of water-MQL is found much better at low cutting speed. ‘Unaffected zones’ are identified at the worn-out tool rake face under water-MQL. High amplitude of vibration (maximum absolute mean value) causes low chip-segmentation ratio. On the contrary, chip reduction coefficient gets truncated with decrement in vibration amplitude. Vibration amplitude has positiveinfluence on degree of chip-curl.