Pelvic bone is a complex and robust load-bearing skeletal structure in the human body, the evolution of which might have been influenced by mechanical loads of daily activities like walking, upright standing, and running. Since the main function of skeletal bones is to provide rigidity to the body and providehard surfaces for muscle attachment as well, in this work we propose a compliance minimization problem to determine whether material distribution guided by topology optimization yields a skeletal structure similar to thepelvic bone under same boundary conditions and volumetric constraints. As bone growth occurs in response to the mechanical loads acting on it, we consider the maximal loads that the pelvic bone may experience for acontinued period of time, namely during running. The running gait cycle is divided into seven phases, and the objective function is a weighted combination of these seven phases. The optimal geometries are compared with the natural hemi-pelvis by measuring shape similarity using Procrustes analysis. Results show that the optimal geometries have good shape similarity in stance phases. We also explore the design space by considering a combination of sequence of phases which is an alternative to the weighted multiple load-case objective function. In all cases, the optimal geometries are stiffer than the hip bone. To validate this result, we conducted compression test experiments on selected optimal geometries and natural hemi-pelvis model of same material andfound that the experimental results prove that topology optimization based optimal geometries are indeed more stiff than the natural hemi-pelvis geometry.