In this paper, an efficient model-predictive control strategy that can be applied to complex multivariable process is presented. A reduced order generalized predictive algorithm is proposed for online applications with reduction in complexity and time elapsed. The complex multivariable process considered in thiswork is a binary distillation column. The reduced order model is developed with a recently proposed hybrid algorithm known as Clustering Dominant Pole Algorithm and is able to compute the full set of dominant poles and their cluster centre efficiently. The controller calculates the optimal control action based on the futurereference signals, current state and constraints on manipulated and controlled variables for a high-order dynamic simulated model of nonlinear multivariable binary distillation column process. The predictive control algorithm uses controlled auto-regressive integrated moving average model. The performance of constraint generalized predictive control scheme is found to be superior to that of the conventional PID controller in terms of overshoot, settling time and performance indices, mainly ISE, IAE and MSE.