• T Nagarajan

      Articles written in Resonance – Journal of Science Education

    • Salvation for Stalled Ribosomes: tmRNA and $trans$-translation in $Escherichia coli$

      T Nagarajan N Arul Muthu Kumaran M Hussain Munavar

      More Details Abstract Fulltext PDF

      Ribosomes stall indefinitely at the 3' end of the mRNAs that lack natural stop codon and also pause anywhere on normal mRNAs during starvation. This pausing traps a considerable population of ribosomes in an inactive state and leads to a deficiency of ribosomes for ongoing protein synthesis. Bac­teria possess a special RNA molecule called the tmRNA (a chimera of tRNA and mRNA), which in association with its binding partner SmpB protein, rescues the stalled ribosomes in a complex multistep process called $trans$-translation. This review aims to discuss the process of $trans$-translation and its involvement in regulating macromolecular processes in bac­teria.

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