• Mandrita Mukherjee

Articles written in Resonance – Journal of Science Education

• Genetic Disorders, Genotyping Techniques and the Emerging Role of Tetra-ARMS-PCR as a Diagnostic Tool

Minor deviations in the script of human life (the genetic code) are known to have major consequences on human health and wellbeing. Even substitution of a single nucleotide (single nucleotide polymorphism – SNP) in the gene sequences can cause diseases. SNP genotyping refers to a variety of techniques that allow simultaneous detection of such changes that can be associated with the pathophysiology of diﬀerent diseases. However, most of the current, cutting-edge SNP geno-typing technologies are complex, expensive, and require post-PCR manipulation. The Tetra–Ampliﬁcation-Refractory Mutation System–Polymerase Chain Reaction (T-ARMS-PCR) method is a simple tool that meets modern diagnostic labo-ratories’ expectations. It is a fast, reliable, and economical method of genotyping for genetic diseases such as $\beta$-thalassemia.

• # Resonance – Journal of Science Education

Current Issue
Volume 27 | Issue 6
June 2022

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