S B Santra
Articles written in Pramana – Journal of Physics
Volume 71 Issue 2 August 2008 pp 193-193
Volume 71 Issue 2 August 2008 pp 359-368
The cytoplasm of a living cell is crowded with several macromolecules of different shapes and sizes. Molecular diffusion in such a medium becomes anomalous due to the presence of macromolecules and diffusivity is expected to decrease with increase in macromolecular crowding. Moreover, many cellular processes are dependent on molecular diffusion in the cell cytosol. The enzymatic reaction rate has been shown to be affected by the presence of such macromolecules. A simple numerical model is proposed here based on percolation and diffusion in disordered systems to study the effect of macromolecular crowding on the enzymatic reaction rates. The model qualitatively explains some of the experimental observations.
Volume 96, 2022
Continuous Article Publishing mode
Click here for Editorial Note on CAP Mode