Production cross-sections of the therapeutic ¹⁰⁵Rh radionuclide from proton-induced reactions on natural palladium target were measured using stacked-foil activation technique combined with high resolution 𝛾-ray spectrometry at the MC50 cyclotron of the Korea Institute of Radiological and Medical Sciences. Note that cyclotron production of the ¹⁰⁵Rh radionuclide from natural palladium target was measured here for the first time. Results are compared with the theoretical values obtained using the model codes TALYS and ALICE-IPPE. Thick target integral yields for the investigated ¹⁰⁵Rh radionuclide were deduced from the threshold energy to 40 MeV. Measured data of the ¹⁰⁵Rh radionuclide are important because of its potential applications in nuclear medicine and/or therapeutic purposes. Optimal production circumstances for the therapeutic ¹⁰⁵Rh radionuclide using a cyclotron are discussed elaborately.

Precise identification and quantification of radioisotope in a sample largely depend on the accuracy of the full-energy peak efficiency of the detector. It is generally observed that the efficiency for a given energy of point-like sources is not the same as the extended source. However, number of correction factors such as detector geometry, photon attenuation, coincidence-summing, etc. may reduce such a difference in efficiency regardless of sources, or they should be considered in the measurement of extended samples. In connection to this, the variation of absolute photopeak efficiency of a high-purity germanium (HPGe) detector with the distances from the surface of the detector as well as with the γ-ray energies were investigated using $\gamma$-ray standard point sources. We present a method to determine the loss of efficiencies in radioactivity measurement of the thin extended radioactive disc samples in comparison to point source.