In this paper, a hierarchy of nonisospectral equations with variable coefficients is derived from the compatibility condition of Toda spectral problem and its time evolution. In order to solve the derived Toda lattice hierarchy, the inverse scattering transformation is utilized. As a result, new and more general exact solutions are obtained. It is shown that the inverse scattering transformation can be generalized to solve some other nonisospectral lattice hierarchies with variable coefficients.
