• Ying Liu

      Articles written in Journal of Genetics

    • Improvement of the sensitivity and resolution of PCR-SSCP analysis with optimized primer concentrations in PCR products

      Xilin Zhu Nifang Niu Yang Liu Te Du Dongmei Chen Xin Wang Harvest F. Gu Ying Liu

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    • Positive association between NTNG1 and schizophrenia in Chinese Han population

      Yuzhang Zhu Huan Yang Yuxia Bi Ying Zhang Chao Zhen Shoufu Xie Heping Qin Jia He Li Liu Ying Liu

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    • Analysis of regulatory networks constructed based on gene coexpression in pituitary adenoma

      Jie Gong Bo Diao Guo Jie Yao Ying Liu Guo Zheng Xu

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      Gene coexpression patterns can reveal gene collections with functional consistency. This study systematically constructs regulatory networks for pituitary tumours by integrating gene coexpression, transcriptional and posttranscriptional regulation. Through network analysis, we elaborate the incidence mechanism of pituitary adenoma. The Pearson’s correlation coefficient was utilized to calculate the level of gene coexpression. By comparing pituitary adenoma samples with normal samples, pituitary adenoma-specific gene coexpression patterns were identified. For pituitary adenoma-specific coexpressed genes, we integrated transcription factor (TF) and microRNA (miRNA) regulation to construct a complex regulatory network from the transcriptional and posttranscriptional perspectives. Network module analysis identified the synergistic regulation of genes by miRNAs and TFs in pituitary adenoma. We identified 142 pituitary adenoma-specific active genes, including 43 TFs and 99 target genes of TFs. Functional enrichment of these 142 genes revealed that the occurrence of pituitary adenoma induced abnormalities in intracellular metabolism and angiogenesis process. These 142 genes were also significantly enriched in adenoma pathway. Module analysis of the systematic regulatory network found that three modules contained elements that were closely related to pituitary adenoma, such as FGF2 and SP1, as well as transcription factors and miRNAs involved in the tumourigenesis. These results show that in the occurrence of pituitary adenoma, miRNA, TF and genes interact with each other. Based on gene expression, the proposed method integrates interaction information from different levels and systematically explains the occurrence of pituitary tumours. It facilitates the tracing of the origin of the disease and can provide basis for early diagnosis of complex diseases or cancer without obvious symptoms.

    • Combined effect between two functional polymorphisms of SLC6A12 gene is associated with temporal lobe epilepsy

      Jingyun Li Hua Lin Fenghe Niu Xilin Zhu Ning Shen Xin Wang Liping Li Aihua Liu Xiaopan Wu Wei Sun Yuping Wang Ying Liu

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      Temporal lobe epilepsy (TLE) is the most common epilepsy subtype with complex genetic structure. A recent study in four populations (Ireland, UK, Australia and Finland) reported an allelic association between betaine/GABA transporter-1 (𝐵𝐺𝑇-1 or 𝑆𝐿𝐶6𝐴12) and mesial temporal lobe epilepsy with hippocampal sclerosis. To demonstrate the association between 𝑆𝐿𝐶6𝐴12 gene polymorphisms and TLE, TaqMan method was used to genotype five single-nucleotide polymorphisms of 𝑆𝐿𝐶6𝐴12 gene in 358 TLE patients and 596 nonepileptic control subjects of Chinese Han origin. Real-time PCR was used to detect the effects of variations on gene expression associated with TLE. Though, the single-marker analysis did not demonstrate allelic association with TLE, rs542736–rs557881 interaction showed significant association. The 𝑆𝐿𝐶6𝐴12 expression levels in peripheral blood mononuclear cells were significantly higher in TLE patients than in control subjects and were correlated to rs542736 G–rs557881 A haplotypes. Our preliminary results suggested combined effect of two common polymorphisms on SLC6A12 gene may be associated with TLE, but the precise mechanism needs further investigation.

    • Longitudinal analysis of APOE-ɛ4 genotype with the logical memory delayed recall score in Alzheimer’s disease


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      No study has focussed on the longitudinal effect of APOE-ɛ4 genotype on the logical memory delayed recall total (LDELTOTAL) score in late-onset Alzheimer’s disease (AD). The LDELTOTAL scores were collected at baseline, 12, 24, 36 and 48 months from 382 participants with AD, 503 with cognitive normal (CN), 1293 with mild cognitive impairment (MCI) in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). A linear mixed model (LMM) was used to investigate the effect of APOE-ɛ4 on the longitudinal changes in the LDELTOTAL scores adjusted for age, gender, education and baseline Mini Mental State Examination score. There were significant differences in LDELTOTAL scores among AD, CN, and MCI (P<0.0001) and among APOE-ɛ4 alleles at baseline (P<0.0001). In the multivariable LMM, elders with 75+ years (P = 0.0051), females (P<0.0001), lower education (P<0.0001), AD and MCI (both P values <0.0001) were associated with decreased LDELTOTAL values, while the individuals with 1 or 2 APOE-ɛ4 allele revealed significantly lower LDELTOTAL scores (both P values<0.0001) compared with individuals without APOE-ɛ4 allele. Further, APOE-ɛ4 alleles had significant interactions with four follow-up visits, where all follow-up visits showed significantly higher LDELTOTAL score. In addition, gender showed interaction with age, education and APOE-ɛ4 with follow-up visits. Our findings provide the first evidence of the effect of APOE-ɛ4 genotype on the logical memory declines related to AD. Further, APOE-ɛ4 alleles showed interactions with gender and follow-up visits.

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