Articles written in Journal of Genetics
Volume 64 Issue 2-3 December 1985 pp 127-134
We consider a simple and analytically solvable model for the spread of a transposable element which has deleterious effects on fitness. Two possible modes are treated, one in which transposition occurs in the newly fertilized zygote, and another in which transposition takes place only in the germ line. In effect, transposition precedes selection in the first case and follows it in the second. This has different long-term consequences depending on the rate of transposition and the values of the selection coefficients. Conditions are derived for the existence of a stable polymorphism with respect to element copy number; the conditions are more stringent in the first case than in the second. It is proved that a polymorphism is impossible unless the copy number decreases fitness in a more-than-muitiplicative fashion.
Volume 68 Issue 3 December 1989 pp 197-200
Volume 72 Issue 2-3 December 1993 pp 85-97 Commentary
It is a long-standing observation that most mutations are recessive. That is, they do not lead to visible phenotypic effects when in heterozygous combination with the wild-type allele. The reason for this has long been debated. Fisher (1930) attributed the observed dominance of the wild type to the action of natural selection at modifier loci. Wright (1929) on the other hand asserted that dominance did not have a selective function
Volume 75 Issue 2 August 1996 pp 233-235
Volume 76 Issue 2 August 1997 pp 161-165 Book Review
Dangerous muddle - Review of
Volume 96 Issue 5 November 2017 pp 717-717 Haldane at 125
Volume 96 Issue 5 November 2017 pp 765-772 HALDANE AT 125
Among many things, J. B. S. Haldane is known for demonstrating how the principle of natural selection can be used to build a mathematical, and in particular quantitative, theory of evolution. However, to the end, he remained open to the idea of other evolutionary mechanisms. In his late writings, he repeatedly drew attention to situations in which natural selection did not operate,was hemmed in by constraints, or worked in a surprising manner. In this respect Haldane stands out among the architects of the Modern Synthesis.
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