UDAYARAJA G. K.
Articles written in Journal of Genetics
Volume 100 All articles Published: 17 February 2021 Article ID 0011 RESEARCH ARTICLE
Human clear cell renal cell carcinoma (ccRCC) is the most common and frequently occurring histological subtype of RCC.Unlike other carcinomas, candidate predictive biomarkers for this type are in need to explore the molecular mechanism of ccRCC andidentify candidate target genes for improving disease management. For this, we chose case–control-based studies from the Gene ExpressionOmnibus and subjected the gene expression microarray data to combined effect size meta-analysis for identifying shared genes signature.Further, we constructed a subnetwork of these gene signatures and evaluated topological parameters during the gene deletion analysis to getto the central hub genes, as they form the backbone of the network and its integrity. Parallelly, we carried out functional enrichment analysisusing gene ontology and Elsevier disease pathway collection. We also performed microRNAs target gene analysis and constructed aregulatory network. We identified a total of 577 differentially expressed genes (DEGs), where 146 overexpressed and 431 underexpressedwith a significant threshold of adjusted
Volume 101, 2022
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