T. C. Carter
Articles written in Journal of Genetics
Volume 50 Issue 2 January 1951 pp 264-267
Volume 50 Issue 2 January 1951 pp 268-276
A hair-waving mutant derived from mice bred by Mr F. W. Coles, and believed to have arisen by spontaneous mutation in 1947, has proved to be indistinguishable from Rex, both phenotypically and genetically. Observations made on heterogeneous material have shown that Rex is not completely dominant, and that there are characteristic phenotypes associated with four other genotypes involving hair-waving mutants, namely,
New segregation data confirm the genetic independence of
Volume 50 Issue 2 January 1951 pp 277-299
These abnormalities have been studied in a large stock of mice carrying
The mutant is compared with other limb mutants, especially polydactyly in cats (Danforth), diplopodia in poultry (Taylor & Gunns), polydactyly in guinea-pigs (Sewall Wright) and congenital absence of the tibia in mice (Rabaud). It may be a recurrence of the last-named.
Volume 50 Issue 2 January 1951 pp 300-306
This paper gives new data on the simultaneous segregation of the mutant luxate,
Volume 50 Issue 2 January 1951 pp 307-323
The importance of mapping the chromosomes of the mouse is stressed, and the need for specially designed stocks for routine linkage testing is pointed out.
The theory of planning linkage tests is outlined, and the new concept of ‘swept radius’ is introduced. This makes it possible (
The composition of five specially designed linkage testing stocks is described. By the use of these stocks a gene can be tested against a little over half of the total genetic map, at the cost of raising about 500 test progeny, which is a considerable improvement over what is at present possible.
An outline is given in Appendix I of the procedure to be adopted for the use of the stocks.
Volume 50 Issue 3 February 1952 pp 399-413
This paper is a review of all published data on the supposed independence of the more important marker genes in the house mouse, using modern statistical methods to combine data from different sources. New data have been added whenever they happened to be available and the published data were lacking or inadequate.
About three-quarters of the necessary tests of the mutual independence of the known linkage groups (except IV) have been made. The least well-tested genes in the groups are
The evidence suggests that linkage groups, I, II and XI may not be independent, and further investigation is needed.
We are indebted to Miss Rita Phillips and Mrs Susan Sobey for assistance with some of the classification of mice and abstraction of data in Table 3; to Miss Mary Lyon and Mr G. A. Clayton for new data on
Volume 51 Issue 1 July 1952 pp 1-6
A mouse, heterozygous for the semi-dominant colour and anaemia mutant
Volume 51 Issue 2 January 1953 pp 373-374
Volume 51 Issue 3 July 1953 pp 441-457
Volume 52 Issue 1 January 1954 pp 1-35
This Paper describes the development of the
Volume 54 Issue 2 May 1956 pp 311-326
It has long been thought that the bleb-induced developmental defects in the Little & Bagg mouse stock were due to a single main gene, but conflicting views were taken about the inheritance of the many other defects found in the stock. Further genetic investigations were a necessary prelude to developmental studies; they have now been made, using stocks in which the incidence of the rarer defects had been raised by selection. It is concluded that pseudencephaly, acrania, renal agenesis, preaxial Polydactyly and syndactyly of the middle digit are all parts of a syndrome which includes the bleb-induced defects and is due to one main gene; and that hydronephrosis, ectopia viscerum and midcerebral lesions are probably further parts of the same syndrome. The occurrence of each part is conditioned by the genetic background as well as the main gene. Linkage tests with markers in all known linkage groups (except group IV) were negative.
Volume 54 Issue 3 November 1956 pp 462-473
Volume 55 Issue 3 December 1957 pp 585-595
J. B. S. Haldane has recently developed a theory for experiments in which induced autosomal recessive lethals in the monse are detected through their linkage with single marker genes in several different chromosomes. A theory is now given for experiments using several marker genes in one chromosome; linkage group V is taken as an example. It is concluded that the two methods may not differ greatly in their efficiency.
Volume 56 Issue 3 December 1959 pp 353-362
A search has been made for X-ray induced recessive autosomal lethal genes in the mouse, using a method proposed by J.B.S. Haldane; the experiment was intended primarily to test the method. It was found that the method is less efficient for measuring mutation rates than the specific-locus method. Data obtained enabled a lower limit to be set for the X-ray dose required to induce one recessive autosomal lethal in spermatogonia, namely 810r; no upper limit could be set. Relevance to human problems is discussed.
Volume 56 Issue 3 December 1959 pp 401-435
The morphology and development of the many defects in mice of the Little & Bagg X-rayed stock have been reinvestigated, in an attempt to resolve the conflicts in the findings of earlier investigators. The observation that blebs occur on pseudencephalic embryos is incompatible with Bonnevie’s hypothesis that they originate as cerebrospinal fluid in the myelencephalon; other observations support Plagens’ hypothesis that the blebs originate as mesenchymal intercellular fluid. No unitary gene action was found. Four pedigrees of causes were constructed covering, respectively, defects of the central nervous system, bleb-induced lesions and defects of the body wall, morphological defects of the hind limbs, and defects of the urogenital system; there were cross-correlations between defects in the first three pedigrees, but the underlying mechanisms were not identified.
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