• SIMING LI

      Articles written in Journal of Genetics

    • Distribution and linkage disequilibrium analysis of polymorphisms of GH1 gene in different populations of pigs associated with body size

      YUNYUN CHENG LIU SONGCAI DAN SU CHAO LU ZHANG XIN QINGYAN WU SIMING LI HAOYU FU HAO YU

      More Details Abstract Fulltext PDF

      Growth hormone (GH) has been considered as a candidate gene for growth and body size in pigs. In this study, polymorphismsof the GH1 gene were evaluated for associations with body size traits in 190 pig individuals. Seventeen single-nucleotidepolymorphisms (SNP$_{s}$) were identified in GH1 gene of the large pig breeds and miniature pig breeds using direct sequencingand genotyped by allele-specific PCR approach. Notably, six (g.237A>G, g.283T>C, g.309A>G, g.318A>G, g.540A>G andg.544A>G) of them were significantly associated with body size, of which three loci (g.283T>C, g.309A>G, g.318A>G)located in the signal-peptide coding region of GH1 gene compose a CGG haplotype for large pigs and TAA haplotype forminiature pigs (P<0.001), two loci (g.540A>G and g.544A>G) located in the second intron of GH1 gene compose a GGhaplotype for large pigs and AA haplotype for miniature pigs (P <0.001). Our results demonstrate that these SNP$_{s}$ in GH1gene are associated with the body size of pigs providing genetic basis for pig breeding with the improved economic benefits.

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