• P. Meera Khan

      Articles written in Journal of Genetics

    • The frequency and effects of consanguineous marriages in Andhra Pradesh

      K. R. Dronamraju P. Meera Khan

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      1. Investigations were started in 1959 in Andhra Pradesh, India, to find out the frequency of different types of consanguineous marriages among the inpatients of King George Hospital in Visakhapatnam, their parents, their children and the parents of school children of two schools in Visakhapatnam and one school in Waltair.

      2. Out of 2,177 marriages investigated, 16·6 per cent were between first cousins, 7·2 per cent with maternal uncles and 6·7 per cent with more distant relatives such as first cousins once removed and second cousins. In all, 30·6 per cent or 666 marriages were consanguineous. The percentage of consanguineous marriages was 39·3 in the inpatients, 25·1 in their parents, 33·8 in their children, and 25·9 in the parents of school children.

      3. The mean coefficient of inbreeding for all marriages was ·02093. It was ·02777 among the inpatients, ·01745 in their parents, ·01862 in their children, and ·01939 in the parents of school children.

      4. The mean coefficient of inbreeding among the parents of inpatients with pulmonary tuberculosis was ·03289 and was significantly higher than the values calculated for other groups. The value of the coefficient among mothers with abortions was ·03040, and in inpatients having children with congenital malformations ·03153.

      5. Out of eightyone inpatients of the Gynaecological ward investigated for sterility, 22·2 per cent of the females married to consanguineous spouses and 16·6 per cent of those married to non-consanguineous spouses were sterile. This result is compared with similar data obtained previously in France, Sweden, the United States and the Susak island of the Adriatic.

    • Glucose-6-phosphate dehydrogenase deficiency in an Indian rural area

      P. Meera Khan

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      Glucose-6-phosphate dehydrogenase deficiency exists in the Godavari valley in the Eastern Ghats of India. Both the partial Negro and the complete Caucasian type are found. The frequency differs greatly in adjacent communities. In the area of Thallavaram it reaches 12.2±2.9%, being less elsewhere.

    • G6PD Punjab, a dialysis sensitive variant of human glucose-6-phosphate dehydrogenase

      C. Verma J. Th. Wijnen P. Meera Khan

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      Erythrocyte samples from 101 individuals, originally from Punjab and living at the time of investigation in England, were screened for glucose-6-phosphate dehydrogenase (G6PD) variants by Beutler’s fluorescent spot test and standard cellulose acetate gel (Cellogel) electrophoresis. All but 2 of the 40 males in the study were found to be indistinguishable from normal G6PD B. One of the variants had 2% of the normal activity and resembled G6PD Mediterranean in electrophoretic behaviour. The other variant showed 52% of the normal activity and migrated slower than G6PD B in Cellogel with about half of the normal band intensity. A set of physicochemical characteristics of the variant determined by conventional methods distinguished it from the variants reported so far. It was designated as G6PD Punjab, and the corresponding allele asG6PD PUN. The most striking feature of G6PD Punjab is a remarkable alteration in its electrophoretic behaviour after dialysis.

    • A 4-base-pair deletion polymorphism in man

      Cor Breukel Carli M. J. Tops P. Meera Khan

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      Partial nucleotide sequencing of C11p11, a probe mapping close to the gene determining familial adenomatous polyposis (FAP) on human chromosome 5, in 4 unrelated persons has revealed a 4-base-pair deletion variant designated DELI at an arbitrary DNA locus D5S71.

      For screening the deletion variants that may frequently occur in the non-coding DNA sequences, we set up a non-invasive procedure which involves DNA amplification by PCR, simple polyacrylamide gel electrophoresis and direct visualisation of alleles under long wave ultraviolet light by ethidium bromide staining.

      The DEL1 polymorphism was found to be determined by a two-allelic co-dominant system in a North European and two Asiatic Indian tribal populations indicating that DEL1 is distributed widely in human populations.

      The approach Used in the present study, which exploits the established methodology, appears to be generally useful in searching for DNA polymorphisms amenable to inexpensive and rapid procedures.

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