INDICO CONSORTIUM
Articles written in Journal of Genetics
Volume 98 All articles Published: 13 February 2019 Article ID 0008 RESEARCH ARTICLE
Genomewide association study of C-peptide surfaces key regulatory genes in Indians
KHUSHDEEP BANDESH GAURI PRASAD ANIL KUMAR GIRI V. SAROJA VORUGANTI NANCY F. BUTTE SHELLEY A. COLE ANTHONY G. COMUZZIE INDICO CONSORTIUM NIKHIL TANDON DWAIPAYAN BHARADWAJ
Insulin is a commonly used measure of pancreatic β-cell function but exhibits a short half-life in the human body. During biosynthesis, insulin release is accompanied by C-peptide at an equimolar concentration which has a much higher plasma half-life and is therefore projected as a precise measure of β-cell activity than insulin. Despite this, genetic studies of metabolic traits haveneglected the regulatory potential of C-peptide for therapeutic intervention of type-2 diabetes. The present study is aimed to search genomewide variants governing C-peptide levels in genetically diverse and high risk population for metabolic diseases—Indians. We performed whole genome genotyping in 877 healthy Indians of Indo-European origin followed by replication of variants with
Volume 98 All articles Published: 26 February 2019 Article ID 0020 RESEARCH ARTICLE
GAURI PRASAD ANIL K. GIRI INDICO CONSORTIUM ANALABHA BASU NIKHIL TANDON DWAIPAYAN BHARADWAJ
Elevated C-reactive protein (CRP) serves as an independent biomarker for acute and chronic inflammation, and is also associated with metabolic diseases. Genomewide loci regulating CRP level in Indian population, a high-risk group for metabolic illness, is unexplored. Therefore, we aimed to discover common polymorphisms associated with plasma CRP level in 4493 Indians of Indo-European origin using genomewide association study. Genomewide strong associations of two known intronic variants in hepatocyte nuclear factor-1 α gene (
Volume 101, 2022
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