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Hong Chen
Articles written in Journal of Genetics
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Volume 89 Issue 2 August 2010 pp 233-236 Research Note
Mou Wang Xinsheng Lai Hui Yu Juqiang Wang Zhong-Qi Chen Xian-Yong Lan Chu-Zhao Lei Hong Chen
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Volume 90 Online resources 2011 pp e53-e57
Yao Xu Jinbiao Liu Xianyong Lan Ya Zhang Chuzhao Lei Chunlei Zhang Dongying Yang Hong Chen
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Volume 91 Online resources 2012 pp e54-e59
Jiajie Sun Jing Xue Chunlei Zhang Xianyong Lan Chuzhao Lei Hong Chen
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Volume 92 Online resources 2013 pp e8-e14
Yujia Sun Jing Xue Wenjiao Guo Mingxun Li Yongzhen Huang Xianyong Lan Chuzhao Lei Chunlei Zhang Hong Chen
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Volume 92 Online resources 2013 pp e53-e59
Two novel SNPs in the coding region of bovine
VDR gene and their associations with growth traitsYuan Gao Dong Liu Wei Ma Aimin Li Xianyong Lan Chunlei Zhang Chuzhao Lei Hong Chen
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Volume 93 Online resources 2014 pp e123-e129
Jiajie Sun Limin Shan Chunlei Zhang Hong Chen
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Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE
Effects of genetic variants of the bovine
WNT8A gene on nine important growth traits in beef cattleYONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ZHENG ZI-JING ZHANG YONG-LONG DANG CHU-ZHAO LEI XIAN-YONG LAN XING-SHAN QI HONG CHEN
WNT-ß-catenin-TCF pathway is involved in carcinogenesis and foetal development. As a member of the WNT gene family, Wnt8A encodes secreted signalling proteins and responds to many biological processes.However, similar research on the effects of genetic variations of Wnt8A gene on growth traits is lacking. Therefore, in this study, polymorphisms of Wnt8A were detectedin 396 animals from Chinese Qinchuan cattle using DNA pool sequencing and PCR-RFLP methods. Four novel single-nucleotide polymorphisms (SNPs) of Wnt8A gene were identified, including three mutations in introns (g.T-445C, g.G244C and g.G910A) and one in exon (g.T4922C). Additionally, we examined the associations of four SNPs with growth traits. The results revealed thatSNP2 (g.G244C) was significantly associated with shoulder height, hip height, body length, hip width, and body weight (P <0.05). SNP3 (g.G910A) also displayed notable effects on hip width (P < 0.05). Meanwhile, the haplotype combination CC-GC-GA-CC was strongly associated with heavier, taller and longer animals (P < 0.05). These results show that the Wnt8A gene may be apotential candidate gene, and the SNPs could be used as molecular markers in early marker-assisted selection in beef cattle breeding programmes.
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Journal of Genetics
Volume 102, 2023
All articles
Continuous Article Publishing mode
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Journal of Genetics | News
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Editorial Note on Continuous Article Publication
Posted on July 25, 2019Click here for Editorial Note on CAP Mode
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