HIMANSHU SHARMA
Articles written in Journal of Genetics
Volume 93 Online resources 2014 pp e48-e55
Abhishek Bhandawat Vikas Sharma Himanshu Sharma Anil Sood Ram Kumar Sharma
Volume 93 Online resources 2014 pp e75-e81
Abhishek Bhandawat Himanshu Sharma Akshay Nag Sanatsujat Singh Paramvir Singh Ahuja Ram Kumar Sharma
Volume 100 All articles Published: 2 June 2021 Article ID 0039 RESEARCH ARTICLE
Prevalence of Y chromosome microdeletion in north Indian infertile males with spermatogenesis defect
HIMANSHU SHARMA UJJAWAL SHARMA SANTOSH KUMAR SHRAWAN KUMAR SINGH RAVI MOHAN S. MAVADURU RAJENDRA PRASAD
Deletion of specific genes present in the long arm of Y chromosome has been identified as the most common genetic cause of defective spermatogenesis. Studies have shown that frequency of Y chromosome microdeletion varies in different geographical location and is related to genetic and environmental influence preponderance. Therefore, the present study was carried out to identify the frequency of Y chromosome microdeletion in the northern region of India and to define subgroup of infertile patients who are critically under more risk of having microdeletion. A total of 292 north Indian infertile males with nonobstructive azoospermia and oligozoospermia were selected for screening the Y chromosome microdeletion. Healthy fertile males (n=100) were also enrolled as control subjects. Frequency of Y chromosome microdeletion in north Indian infertile males was found to be about 8.5%, with azoospermia factor (AZFc) region as the most susceptible region for microdeletion. Comparatively microdeletion is more common in patients with nonobstructive azoospermia thanoligozoospermia (9.2% versus 7.1%). Statistical analysis also revealed that patients with hormonal FSH level between 20 and 40 mIU/mL have more chances of harbouring microdeletion. Hence, the present study highlights the importance of screening AZFc region among infertile patients with very high serum FSH value.
Volume 102, 2023
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