Ischaemic stroke is a multifactorial disease. Genetic polymorphisms involved in lipid, inflammatory and thromboticmetabolisms play an important role in the development of ischaemic stroke. The present study aimed to assess the relationshipbetweenT1131C APOA5andSG13S114 ALOX5APpolymorphisms and the risk of ischemic stroke in 175 cases and 201 con-trols. Genotyping was performed by high resolution melting and polymerase chain reaction restriction fragment length poly-morphism methods. In the case ofT-1131C APOA5

, a modest risk of ischaemic stroke was noticed with CC (OR: 2.86; 95%CI

=1.24–6.58; Pc

=0.039) and C allele (OR: 1.54; 95% CI

=1.01–2.33; Pc

=0.014). ForSG13S114 ALOX5AP

, a signifi-cant association was observed among subjects with TT (OR: 2.57; 95% CI

=1.49–4.83; Pc

=0.009) and T allele (OR: 1.59;95% CI

=1.16–2.19; Pc

=0.008). According to the risk factors of ischaemic stroke, a positive correlation was observed onlybetweenSG13S114variant ofALOX5APgene and hypertension (Pc

=0.026). Despite lower sample size,T-1131C APOA5andSG13S114variants could be considered an independent genetic risk factor of ischaemic stroke in Moroccan population