Gillian M. Truslove
Articles written in Journal of Genetics
Volume 51 Issue 1 July 1952 pp 115-122
The skull variants interfrontal and parted frontals originally described by Keeler are shown to have a complex genetic basis.
Volume 52 Issue 3 September 1954 pp 589-602
Two new variants of the presphenoid of the mouse are described. They are sutures in the preoptic root and reduction or absence of the postoptic root of the ala orbitalis. The former variant arises during ossification, while the latter is preformed in cartilage. Both variants occur in different frequencies in three inbred strains of mice. They are regarded as quasi-continuous variations, and their behaviour in crosses between two of the pure fines is best explained on a multifactorial basis. Additional data for interfrontal and parted froutals described previously indicate a similar genetic basis for these two variants.
Volume 54 Issue 1 January 1956 pp 64-86
The fidget gene causes abnormalities in the gross structure of the vestibular part of the membranous labyrinth. The horizontal semicircular canal and its crista ampullaris are both missing. The superior and posterior canals remain rudimentary in form, but the sense organs associated with them are normal.
The abnormalities of the membranous labyrinth lead to anomalies in the form of the osseous labyrinth and there is no subarcuate fossa.
The parafloccular lobes of the cerebellum are displaced into an abnormal position under the other lateral lobes.
The eyes and lens are reduced in size in fidgets, and the latter may remain in contact with the overlying ectoderm, which is probably a contributory cause of corneal ulcers.
The lachrymal glands are missing and there are marked corneal ulcers in adult mice.
In some fidget animals there is no mandibular canal.
The fidget gene increases the number of fusions between certain bones of the skull and in the tarsals.
In some fidgets there is a dislocation of the hip and in most fidgets the acetabulum is shallower than normal.
The fidget gene increases the incidence of polydactylism.
It is believed that the abnormalities of the membranous labyrinth are responsible for those of the osseous labyrinth and. still more indirectly, for the displacement of the paraflocculus. Similarly, the reduction of the lens is probably responsible for the reduction of the size of the eyes as a whole; and it is believed that the absence of the lachrymal glands (and with it the development of the corneal ulcers) is somehow connected with the rest of the eye anomalies. It is supposed that ear and eye anomalies may have a common cause the nature of which is, however, completely obscure. The physiological links of the statistical effects of the fidget gene with the more constant features of the syndrome remain to be discovered.
Volume 55 Issue 2 July 1957 pp 288-312
The effect of oats, wheat, buckwheat and barley on the skeleton of offspring from. parents fed on these diets has been analysed, and the results correlated with the effect on birth weight and weight at 21 days.
In nineteen out of twenty-two characters Searle’s and our own experiments with oats were in agreement.
All four diets had a similar effect on the skeleton in the majority of cases. In general oats had the least deleterious effect on the mice, but its effect on the skeleton was the strongest. Barley is by far the poorest diet, but has a comparatively small effect on the skeleton.
The characters used are quasi-continuous and in about ten variants a reduction in the size of the animals is the underlying cause of the changes produced by the deficient diets.
Five new variants are also described for the first time.
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