D. G. Catcheside
Articles written in Journal of Genetics
Volume 26 Issue 2 October 1932 pp 143-178
Volume 27 Issue 1 March 1933 pp 45-69
The chromosome linkages in a number of
Evidence of interference between chiasmata is also brought forward and discussed. It appears likely that short chromosomes have a higher mean frequency relative to their length than have longer chromosomes.
Volume 35 Issue 2 November 1937 pp 315-320
The two closed
Volume 36 Issue 2 July 1938 pp 307-320
The frequency of induced structural changes of chromosomes observed in
The high frequency (11%) of rearrangements, which on the contact hypothesis would require three or more threads in contact at one point, makes it unlikely that the chromosomes are ever in contact before, during or after irradiation unless they completely fill the treated nucleus.
The high frequency of inversions in one chromosome arm, relative to interchanges between different arms, demonstrates a spatial preference either in the refusion of breakage ends or in a grouping of original breaks through a contact or analogous mechanism.
Volume 36 Issue 2 July 1938 pp 321-328
A study of X-ray induced interchanges in maize has shown, in the
Volume 38 Issue 1-2 July 1939 pp 345-352
In an X-ray induced interchange of
Volume 44 Issue 2-3 December 1942 pp 216-245
Volume 45 Issue 2 October 1943 pp 186-196
1. The coefficients of chromatid breakage (compare Table 4) are highest with Ag
2. This is interpreted to mean that only the densely ionizing ‘tails’ of the electron tracks are effective in chromosome breakage, and that the ‘tails’ have a higher efficiency only where they traverse the chromatid; for the track of an Al
3. The probability of survival of chromatid breaks is the same in the pollen-tube nucleus as in the pollen-grain nucleus.
4. The two chromatids of a chromosome are in contact 24 hr. before metaphase in the pollen-grain nucleus. They are slightly separated 15 hr. before metaphase in the pollen-tube nucleus.
5. The probability of interchange in the pollen-tube nucleus is reduced by the different method of packing of the chromosomes in a long cylindrical nucleus as compared with the spherical one of the pollen grain.
Volume 47 Issue 1 July 1945 pp 1-9
The rate of X-ray induction of dominant lethals in the sperm of the Oregon-R stock of
The rate of depression of the sex ratio of females to males, founded on our own and other data, is about 2·5% per 1000 r.
Volume 47 Issue 1 July 1945 pp 10-24
The suggestion is put forward that radiation-induced recessive lethals, or a large proportion of them, are due to chromosome breaks. About one-third of all the chromosome breaks primarily induced by the radiation are lethals. If the break restitutes, a lethal unaccompanied by chromosomal aberration (type A lethal) results. If the break takes part in chromosome interchange a type C lethal, which is associated with chromosomal structural change, results. Arguments are given against the alternative position-effect explanation of type C lethals.
A quantitative theory of dominant lethals is developed on the basis that the dominant lethals are a mixture of single breaks which fail either to restitute or to interchange but instead undergo sister-union, and of non-viable chromosomal structural changes involving two or more breaks. The experimental curve of variation with dose of the yield of dominant lethals is successfully fitted, and also the curve of the yield of viable structural changes.
It is shown that the recessive lethal and the dominant lethal theories are consistent in that they require the same postulated number of primarily produced chromosome breaks per unit dose (namely, 0·75 breaks per sperm per 1000 r.). Experiments on the distortion of the sex ratio in the progeny of irradiated males with ring-shaped or rod-shaped
Volume 47 Issue 1 July 1945 pp 25-40
Volume 47 Issue 1 July 1945 pp 41-50
At various times it has been proposed that the size of the gene can be estimated from experiments on the yield of mutations obtained with known doses of X-rays. The assumptions involved in calculations of this sort are discussed, and some of the objections which have been raised against them answered. It is pointed out that similar assumptions, applied to experiments on the inactivation of enzymes and viruses, lead to estimates of the sizes of these bodies correct to a factor of two in diameter. The estimate arrived at for the size of the gene in
Volume 47 Issue 2 January 1946 pp 113-136
Volume 47 Issue 2 January 1946 pp 137-149
Volume 48 Issue 1 April 1947 pp 31-42
The break is 1·7 units from the
Theories of the mechanism of position effect are considered, but the
Volume 48 Issue 1 April 1947 pp 99-110
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