Articles written in Journal of Genetics
Volume 94 Issue 4 December 2015 pp 651-659 Research Article
Variants in the interleukin-1 alpha and beta genes, and the risk for periodontal disease in dogs
C. Albuquerque F. Morinha J. Magalhães J. Requicha I. Dias H. Guedes-Pinto E. Bastos C. Viegas
Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria. In humans, polymorphisms in the 𝐼𝐿1𝐴 and 𝐼𝐿1𝐵 genes are the most well-studied genetic polymorphisms associated with periodontal disease (PD). In contrast to human, there is a lack of knowledge on the genetic basis of canine PD. A case–control study was conducted in which a molecular analysis of dog 𝐼𝐿1𝐴 and 𝐼𝐿1𝐵 genes was performed. Of the eight genetic variants identified, seven in 𝐼𝐿1𝐴 gene and one in 𝐼𝐿1𝐵 gene, 𝐼𝐿1𝐴/1_g.388A>C and 𝐼𝐿1𝐴/1_g.521T>A showed statistically significant differences between groups (adjusted OR (95% CI): 0.15 (0.03–0.76), 𝑃 = 0.022; 5.76 (1.03–32.1), P = 0.046, respectively). It suggests that in the studied population the 𝐼𝐿1𝐴/1_g.388C allele is associated with a decreased PD risk, whereas the 𝐼𝐿1𝐴/1_g.521A allele can confer an increased risk. Additionally, the 𝐼𝐿1𝐴/2_g.515G>T variation resulted in a change of amino acid, i.e. glycine to valine.
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