Analabha Basu
Articles written in Journal of Genetics
Volume 82 Issue 1-2 April 2003 pp 7-12
Analabha Basu Partha P. Majumder
We have compared two statistical methods of estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences, which have been proposed by Templeton (1993) and Bandelt
Volume 94 Issue 1 March 2015 pp 105-113 Research Article
Ankita Chatterjee Analabha Basu Abhijit Chowdhury Kausik Das Neeta Sarkar-Roy Partha P. Majumder Priyadarshi Basu
Nonalcoholic fatty liver disease (NAFLD) is a distinct pathologic condition characterized by a disease spectrum ranging from simple steatosis to steato-hepatitis, cirrhosis and hepatocellular carcinoma. Prevalence of NAFLD varies in different ethnic groups, ranging from 12% in Chinese to 45% in Hispanics. Among Indian populations, the diversity in prevalence is high, ranging from 9% in rural populations to 32% in urban populations, with geographic differences as well. Here, we wished to find out if this difference is reflected in their genetic makeup. To date, several candidate genes and a few genomewide association studies (GWAS) have been carried out, and many associations between single nucleotide polymorphisms (SNPs) and NAFLD have been observed. In this study, the risk allele frequencies (RAFs) of NAFLD-associated SNPs in 20 Indian ethnic populations (376 individuals) were analysed. We used two different measures for calculating genetic risk scores and compared their performance. The correlation of additive risk scores of NAFLD for three Hapmap populations with their weighted mean prevalence was found to be high (𝑅2 = 0.93). Later we used this method to compare NAFLD risk among ethnic Indian populations. Based on our observation, the Indian caste populations have high risk scores compared to Caucasians, who are often used as surrogate and similar to Indian caste population in disease gene association studies, and is significantly higher than the Indian tribal populations.
Volume 98 All articles Published: 26 February 2019 Article ID 0020 RESEARCH ARTICLE
GAURI PRASAD ANIL K. GIRI INDICO CONSORTIUM ANALABHA BASU NIKHIL TANDON DWAIPAYAN BHARADWAJ
Elevated C-reactive protein (CRP) serves as an independent biomarker for acute and chronic inflammation, and is also associated with metabolic diseases. Genomewide loci regulating CRP level in Indian population, a high-risk group for metabolic illness, is unexplored. Therefore, we aimed to discover common polymorphisms associated with plasma CRP level in 4493 Indians of Indo-European origin using genomewide association study. Genomewide strong associations of two known intronic variants in hepatocyte nuclear factor-1 α gene (
Volume 100 All articles Published: 12 November 2021 Article ID 0084 RESEARCH NOTE
PARIKSHIT KAKATI SUMAN KALYAN PAINE CHANDRA KANTA BHATTACHARJEE CHANDRIKA BHATTACHARYYA AMIT SHARMA DEBABRATA PHUKAN NAGENDRA NATH BARMAN ANALABHA BASU
Volume 102, 2023
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