In Australia, water resource management is a major socio-economic and environmental issue and an essential component of progress. This is more acute in arid and semi-arid regions of Australia. The Southern Flinders Ranges townships of Quorn and Hawker in common with much of the Flinders Ranges suffers from a lack of reliable data to help water resource managers. This paper discusses the delineation and assessment of groundwater potential zones using remote sensing and geospatial techniques in the region, using multi-criteria analyses. The study integrates many thematic layers (rainfall, lithology, lineament density, topographic wetness, slope and aspect) in a GIS environment in order to identify groundwater potential zones. Weights are assigned to class attributes within and between each thematic data layer using an Analytical Hierarchy Process based on the relative importance of each layer. The weighted thematic data layers are then combined to produce a probability of groundwater potential zone map of each study area. The groundwater potential zones were verified with available water data, and showed consistency with the interpretations.