Stable carbon and oxygen isotopic analyses of the planktonic foraminifera (Globigerinoides ruber) from a deep sea sediment core (GC-1) in the Andaman Sea show high glacial-to-Holocene δ¹⁸O amplitude of 2.1%o which is consistent with previously published records from this marginal basin and suggest increased salinity and/or decreased temperature in the glacial surface waters of this region. A pulse of¹⁸O enrichment during the last deglaciation can be attributed to a Younger Dryas cooling event and/or to a sudden decrease of fresh water influx from the Irrawady and Salween rivers into the Andaman Sea. High δ¹³C values observed during the isotopic stages 2 and 4 are probably due to the enhanced productivity during glacial times in the Andaman Sea.