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- Volume 133 All articles Published: 30 April 2021 Article ID 0045
  
  Synthesis, X-ray structures and cytotoxic effects of a Cu(II)- and a Zn(II) thiosemicarbazones on human epidermoid carcinoma cell A431
  
  CHINMOY BISWAS ARNAB CHATTERJEE SONALI BHATTACHARYA DEBA PRASAD MANDAL SHAMEE BHATTACHARJEE RAJARSHI GHOSH
  
  More Details Abstract Fulltext PDF
  
  Thiosemicarbazone metal complexes [Cu(L)(2-benzpy)]ClO₄ (1) and [Zn(L)₂] (2) [L = 2-benzoylpyridine-N(4)-methyl-3-thiosemicarbazone), 2-benzpy = 2-benzolylpyridine] were synthesized and X-raycrystallographically characterized. The metal centre in compound 1 has a distorted square planar geometry while in compound 2, the metal centre has a distorted octahedral geometry. Both the molecules induce cytotoxic effects on A431 skin carcinoma cell line in 24 h incubation and significantly enhances hypoploid cell population in cell cycle phase distribution below IC₅₀ dose. Application of both the two molecules exhibit apoptotic induction and genotoxic activity in 24 h exposure.

Journal of Chemical Sciences

Volume 135, 2023
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