• Zhong-Cheng Song

      Articles written in Journal of Chemical Sciences

    • Synthesis, antimicrobial activity of lamotrigine and its ammonium derivatives

      Yong Qian Peng-Cheng Lv Lei Shi Rui-Qin Fang Zhong-Cheng Song Hai-Liang Zhu

      More Details Abstract Fulltext PDF

      Antiepileptic drug lamotrigine and its thirteen ammonium salt complexes (4a-4m) were synthesized and characterized by IR, elemental analysis, 1H-NMR, and MS spectral methods. Many of the ammonium salts (4a-4m) were first reported. Furthermore, the crystal structure of compound 3 was determined by single crystal X-ray diffraction analysis. All these complexes were tested in vitro for their antibacterial activity (Bacillus subtilis, Staphylococcus aureus, Enterococus faecalis, Escherichia coli, Pseudomonas aeruginosa and Enterobacter cloacae). The results indicated that most of the complexes showed good antibacterial activity against Gram-positive (B. subtilis, S. aureus and S. faecalis), but showed mild, even inactive against Gram-negative bacterial strains.

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