Articles written in Journal of Chemical Sciences

    • Voltammetric determination of dopamine and norepinphrine on a glassy carbon electrode modified with poly (L-aspartic acid)

      Zhangyu Yu Xiaochun Li Xueliang Wang Xinying Ma Xia Li Kewei Cao

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      A convenient and useful method for the voltammetric determination of dopamine (DA) and norepinphrine (NE) based on poly(L-aspartic acid) modified glassy carbon electrode (GCE) is reported in this paper. The modified electrode exhibits excellent electro-catalytic activities for the oxidation-reduction of DA and NE, as well as eliminating the interference of ascorbic acid (AA) and uric acid (UA). Factors influencing the detection processes are optimized and the kinetic parameters are calculated. Under the optimal conditions, the anodic peak currents of DA and NE are linear with their concentration and the detection limits (S/N = 3) are $1.0 \times 10^{−9}$ mol L-1 for DA and $4.31 \times 10^{−9}$ mol L-1 for NE, respectively. The practical application of this method is demonstrated by determining the concentration of NE and DA in injection which is commercially available with satisfactory results. Compared with other electrochemical methods, this method is simple, highly selective and sensitive.

    • A novel enzymatic biosensor for detection of intracellular hydrogen peroxide based on 1-aminopyrene and reduced graphene oxides


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      An electrochemical sensor for hydrogen peroxide (H2O2) detection was established using 1-aminopyrene (AP) as a linker between horseradish peroxidase (HRP) and reduced graphene oxides (rGO) modified glassy carbon electrode. The AP can combine with HRP via a covalent bond and combine withrGO via π-π conjugation. The covalent bond linkages can prevent the enzymes leaching of the enzymes and the π-π conjugate combination can facilitate electrons transfer, which plays synergistic effects to improve the performance of this sensor. The electrochemical activity of the HRP-AP/rGO was described by cyclic voltammetry, alternating current impedance and amperometric techniques. Under the optimal conditions, the biosensor showed a wide linear range from 1.5 μM to 28.5 μM and a low detection limit of 0.5 μM with good stability and high selectivity, confirming that the sensor is well-suited for the detection of H2O2 during biological processes.

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