• TUSHAR TYAGI

      Articles written in Journal of Chemical Sciences

    • Selective sensing of thiols by aryl iodide stabilized fluorescent gold cluster through turn-off excimer emission caused by ligand displacement

      JASMIN KUBAVAT JAYDEV THAKARDA TUSHAR TYAGI SAGAR BHOWMIK PRASENJIT MAITY

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      Here we report fluorescence quenching based detection of selected ‘‘Thiol’’ molecules byemploying a luminescent gold cluster through ligand displacement strategy. First, an aryl iodide (2-Iodonaphthalene,NP) and polyvinylpyrrolidone (PVP) mixed ligand stabilized gold cluster was synthesized with astrong fluorescence signal originated from excimer of 2-Iodonaphthalene ligands grafted on gold nano surface.Among different small molecule-based ligands, thiol (R-SH) forms a strong bond with gold nanoparticles.Anticipating this property, we have found that displacement of 2-Iodonaphthalene ligand from goldnanoparticle surface by thiols results in the sensitive detection of thiols through the quenching of emission ofgold cluster. The selectivity for detection of different tested analytes follows the order: GSH>Cys>hCywhereas, other non-thiol based amino acids and common salts are innocent towards fluorescence response.Easy synthesis of the fluorescent gold cluster, selective sensing of small thiol molecules, high Stern-Volmerconstant (KSV=3.3×106 M-1) and ultralow detection limit (LOD of 35 nM) are notable features of the presentreport.

      A fluorescence turn-off chemosensor has been developed for sensing selected ‘thiol’ molecules by employing 2-Iodonaphthalene and polyvinylpyrrolidone (PVP) mixed ligand stabilized luminescent gold cluster through ligand displacement strategy.

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