• Shrabani Sen

      Articles written in Journal of Chemical Sciences

    • Growth and decay of large fluctuations far from equilibrium

      Shrabani Sen Syed Shahed Riaz Deb Shankar Ray

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      We have explored the weak noise limit of stochastic processes in nonlinear dissipative systems which admit of stable dynamical attractors in absence of noise. An interesting `detailed balance’ like condition in the steady state which is manifested in the time reversal symmetry between growth and decay of fluctuation far from equilibrium, similar to what is observed in thermally equilibrated systems, is demonstrated.

    • Stochastic optimization-based study of dimerization kinetics

      Srijeeta Talukder Shrabani Sen Ralf Metzler Suman K Banik Pinaki Chaudhury

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      We investigate the potential of numerical algorithms to decipher the kinetic parameters involved in multi-step chemical reactions. To this end, we study dimerization kinetics of protein as a model system. We follow the dimerization kinetics using a stochastic simulation algorithm and combine it with three different optimization techniques (genetic algorithm, simulated annealing and parallel tempering) to obtain the rate constants involved in each reaction step. We find good convergence of the numerical scheme to the rate constants of the process. We also perform a sensitivity test on the reaction kinetic parameters to see the relative effects of the parameters for the associated profile of the monomer/dimer distribution.

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