Articles written in Journal of Chemical Sciences
Volume 106 Issue 3 June 1994 pp 809-809
Volume 106 Issue 5 October 1994 pp 1253-1258 Carbohydrates and Lipids: Synthesis and Outlook
An overview of the current trends in the lipid design for specific applications has been presented. Lipids with different surface charge and hydrophobic backbone undergo aggregation to produce lamellae or bilayer and multilayer vesicles in aqueous media. Various aspects of present development of chiral superstructures and enzyme-mimics have been discussed. Utility of these molecules for potential applications in immunomodulation and sustained drug-delivery systems is also summarized.
Volume 114 Issue 3 June 2002 pp 197-201
Five novel cationic lipids with fully or partially
Volume 115 Issue 5-6 October 2003 pp 613-619
Nanoparticles have properties that can be fine-tuned by their size as well as shape. Hence, there is significant current interest in preparing nano-materials of small size dispersity and to arrange them in close-packed aggregates. This manuscript describes ways of synthesising gold nanoparticles using a metal-chelator derivative
Volume 122 Issue 2 March 2010 pp 97-107 Perspective Article
This article describes recent developments in the design and implementation of various strategies towards the development of novel therapeutics using first principles from biology and chemistry. Strategies for multi-target therapeutics and network analysis with a focus on cancer and HIV are discussed. Methods for gene and siRNA delivery are presented along with challenges and opportunities for siRNA therapeutics. Advances in protein design methodology and screening are described, with a focus on their application to the design of antibody based therapeutics. Future advances in this area relevant to vaccine design are also mentioned.
Volume 135 All articles Published: 18 January 2023 Article ID 0007
Pyrene-based fluorogenic amphiphilic probe (1) has been synthesized, which can form a thixotropic(injectable) hydrogel in the aqueous medium. The biocompatible hydrogel, so formed, is involved inthe thermoresponsive, sustainable delivery of two anticancer drugs, Doxorubicin (DOX) and Mitoxantrone(MT). A substantial difference in the extent of drug release is noticed at 25 and 37°C, even at physiological pH. The cumulative releases of ~80% and ~70% for DOX and MT, respectively, from the drug-loaded hydrogel samples, are observed for 72 h. In both cases, drug molecule release follows zero-order kinetics andnon-Fickian diffusion pathways. The excellent stability of 1 against proteinase enzyme suggests that thepresent system can be used for sustainable, targeted release of drug molecules under in-vivo conditions. Asexpected, DOX-loaded hydrogels kill cancer cells more efficiently than the free drug (i.e., DOX).
A pyrene-based amphiphilic probe has been synthesized, which can form a thixotropic hydrogel in the aqueous medium. The biocompatible hydrogel was involved in the thermoresponsive, sustainable delivery of two anticancer drugs, Doxorubicin (DOX) and Mitoxantrone (MT). Moreover, the DOX-loaded hydrogel could kill cancer cells more efficiently than the free drug.
Volume 135, 2023
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