S S BARI
Articles written in Journal of Chemical Sciences
Volume 128 Issue 11 November 2016 pp 1745-1753 Regular Article
Studies towards C-3 functionalization of β-lactams using substituted allylsilanes
An effective and stereoselective synthesis of 3-(1'-methyl/phenylallyl)-3-phenylthio-β-lactams (3/4) using substituted allylsilane and Lewis acid is described. The reaction leads to the formation of a mixture of C-3 substituted allyl β-Lactams. However, these compounds on desulphurisation using tri-n-butyltinhydride and Raney Ni provide two separable diastereomers of the reduced product.
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