• SHANKAR R THOPATE

      Articles written in Journal of Chemical Sciences

    • Pyruvic acid-catalyzed one-pot three-component green synthesis of isoxazoles in aqueous medium: a comparable study of conventional heating versus ultra-sonication

      SANTOSH R DESHMUKH ARCHANA S NALKAR SHANKAR R THOPATE

      More Details Abstract Fulltext PDF

      A mild and efficient route for the one-pot synthesis of isoxazole derivatives has been developedusing pyruvic acid as a catalyst under an aqueous medium. The reaction was carried out under conventional aswell as ultrasonic conditions to afford the desired product in good yield. The features of this protocol are theuse of environmental-friendly, commercially available, biodegradable catalyst, use of biologically safe solvent, simple experimental procedure and short reaction times. The given protocol can be a better alternativefor the synthesis of 4H-isoxazol-5-one derivatives as compared to traditional methods.

      Synopsis: A mild and efficient route for the one pot synthesis of isoxazole derivatives has been developed using pyruvic acid as a catalyst under aqueous medium. The reaction was carried out under conventional as well as ultrasonic condition to afford the desired product in good yield.

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