A mild and efficient route for the one-pot synthesis of isoxazole derivatives has been developedusing pyruvic acid as a catalyst under an aqueous medium. The reaction was carried out under conventional aswell as ultrasonic conditions to afford the desired product in good yield. The features of this protocol are theuse of environmental-friendly, commercially available, biodegradable catalyst, use of biologically safe solvent, simple experimental procedure and short reaction times. The given protocol can be a better alternativefor the synthesis of 4H-isoxazol-5-one derivatives as compared to traditional methods.

Synopsis: A mild and efficient route for the one pot synthesis of isoxazole derivatives has been developed using pyruvic acid as a catalyst under aqueous medium. The reaction was carried out under conventional as well as ultrasonic condition to afford the desired product in good yield.