SAM P DE VISSER
Articles written in Journal of Chemical Sciences
Volume 133 All articles Published: 18 June 2021 Article ID 0061
The cytochrome P450 enzymes are important enzymes in the liver that trigger drug metabolismreactions. In biotechnology and biomimetic chemistry, synthetic models of the active species of P450 havebeen developed and designed and often react differently. Here, we investigate a biomimetic P450 modelcomplex with phthalocyanine equatorial ligand rather than heme or porphyrin and with and without four
Synopsis: A series of density functional theory studies are presented on the electronic properties of a phthalocyanine ligated iron(IV)-oxo cation radical species and its reactivity with para-substituted thioanisole substrates. The studies show that despite the fact the reactant is electronically different from cytochrome P450 Compound I, it should react with sulfides in a concerted synchronous manner efficiently.
Volume 134, 2022
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