• S K Srivastava

      Articles written in Journal of Chemical Sciences

    • Functional properties and electroanalytical selectivity of some anion exchange membranes

      S K Srivastava Vandana Sahgal C K Jain

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      Heterogeneous membranes of Fe(III)-Zr(IV), Cr(III)-Zr(IV) mixed hydrous oxides and one doped with Sn(II) ion have been prepared using polystyrene as a binding material. Functional properties like water content, porosity, swelling, electrolyte absorption and conductance of these membranes have been determined in various anionic forms and correlated with their electroanalytical selectivity.

    • Synthesis and pharmaceutical importance of 2-azetidinone derivatives of phenothiazine

      Ritu Sharma Pushkal Samadhiya S D Srivastava S K Srivastava

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      A new series of 𝑁-[3-(10𝐻-phenothiazin-1-yl)propyl]-4-(substituted phenyl)-3-chloro-2-oxo-1-azetidinecarboxamide 4(a-m) have been synthesized from phenothiazine in four steps. Phenothiazine on reaction with Cl(CH2)3Br at room temperature gave 1-(3-chlorophenyl)-10𝐻-phenothiazine, 1. The compound 1 yielded the condensation product with urea at room temperature, 𝑁-[3-(10𝐻-phenothiazin-1-yl)propyl]urea 2. The compound 2 on further reaction with several substituted aromatic aldehydes produced 𝑁-[3-(10𝐻-phenothiazin-1-yl)propyl]-$N'$-[(substituted phenyl)methylidene]-urea 3(a-m). The compounds 3(a-m) on treatment with ClCH2COCl in the presence of Et3N furnished final products 4(a-m). The structures of all the newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and FAB-Mass spectra and chemical methods. All the final synthesized compounds were evaluated for their antibacterial, antifungal and antitubercular activities which displayed acceptable activities.

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