• Rohit Sharma

      Articles written in Journal of Chemical Sciences

    • Synthesis, molecular structures and ESI-mass studies of copper(I) complexes with ligands incorporating N, S and P donor atoms

      Tarlok S Lobana Arvinder Kaur Rohit Sharma Madhu Bala Amanpreet K Jassal Courtney E Duff Jerry P Jasinski

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      Equimolar reaction of copper(I) bromide with 2-thiouracil (tucH2) in acetonitrile-methanol formed a light yellow solid which on subsequent treatment with a mole of triphenyl phosphine (PPh3) in chloroform has yielded a sulfur-bridged dinuclear complex, [Cu2Br2 (𝜇-S-tucH2)2 (PPh3)2]·2CHCl3 1. A reaction of copper(I) bromide with two moles of 2,4-dithiouracil (dtucH2) in acetonitrile-methanol followed by addition of two moles of PPh 3 , designed to form [Cu(𝜇-S,S-dtuc)2 (PPh3)4 Cu] 2a, instead resulted in the formation of previously reported polymer, {CuBr(𝜇-S,S-dtucH2)(PPh3)}n 2. Reaction of copper(I) iodide with 2- thiouracil (tucH2) and PPh3 in 1:1:2 molar ratio (Cu:H2 tuc:PPh3) as well as that of copper(I) thiocyanate with pyridine-2-thione (pySH) or pyrimidine-2-thione (pymSH) and PPh3 in similar ratio, yielded an iodo-bridged unsymmetrical dimer, [(PPh3)2 (𝜇-I)2 Cu(PPh3)] 3 and thiocyanate bridged symmetrical dimer, [(PPh3)2 Cu(𝜇- N,S- SCN)2 Cu(PPh3)2] 4, respectively. In both the latter reactions, thio-ligands which initially bind to Cu metal center, are de-ligated by PPh3 ligand. Crystal data: 1, P21/c: 173(2) K, monoclinic, a, 13.4900(6); b, 17.1639(5); c, 12.1860(5) Å; 𝛽, 111.807(5)° ; R, 5.10%; 2, Pbca: 296(2) K, orthorhombic, a, 10.859(3); b, 17.718(4); c, 23.713(6) Å; 𝛼 = 𝛽 = 𝛾 , 90° ; R, 4.60%; 3, P2 1 : 173(2) K, monoclinic, a, 10.4208(7); b, 20.6402(12); c, 11.7260(7) Å; 𝛽, 105.601(7)° ; R, 3.97%; 4, P-1: 173(2) K, triclinic, a, 10.2035(4); b, 13.0192(5); c, 13.3586(6) Å; 𝛼, 114.856(4); 𝛽, 92.872(4)° ; 𝛾 , 100.720(4) ° ; R, 3.71%. ESI-mass studies reveal different fragments of complexes.

    • Triethylenetetramine complexes of cobalt(III) having anion binding sites: synthesis, characterisation, crystal structure, anti-bacterial and anti-cancer properties of [Co(trien)(NO2)2]2Cr2O7 and [Co(trien)(NO2)2]SCN


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      Crystals of cobalt(III) salts dinitro(triethylenetetramine)cobalt(III) dichromate [Co(trien)(NO2)2]2Cr2O7 (1) and dinitro(triethylenetetramine)cobalt(III) thiocyanate [Co(trien)(NO2)2]SCN (2) have been synthesized to investigate [Co(trien)(NO2)2]+ cation as a promising host to capture dichromate and thiocyanate anions. The characterization of the newly synthesized compounds was accomplished by elemental analysis and spectroscopic techniques (IR, UV/visible and 1H-NMR) and solubility product measurement. The asymmetric unit of complex 1 has a half dichromate anion and one [Co(trien)(NO2)2]+ cation while that of complex 2 has one thiocyanate anion and one [Co(trien)(NO2)2]+ cation as divulged by X-ray structure determination. The structural investigation exhibited that the crystal lattice was stabilized by second sphere hydrogen bonding interactions such as N–Htrien...O (dichromate), C–Htrien...O (dichromate), N–Htrien...N (thiocyanate) and C–Htrien...N (thiocyanate) interactions resulting in the formation of supramolecular assemblies. The complexes 1 and 2 were further examined for antibacterial activity and the findings unveiled moderate activity against gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa species. These complexes were also scrutinized for anti-proliferative activity against malignant PANC-1 cells using MTT cell survival analysis. Complex 1 exhibited remarkable anticancer activity whereas complex 2 has comparatively lesser anticancer potential

      Crystals of cobalt(III) ion [Co(trien)(NO2)2].X (X= ½.Cr2O7 (1)/ SCN (2)) have been synthesized and characterized by various spectroscopic and analytical techniques. Structural study of 1 and 2 were established and divulge formation of supramolecular assemblies through H-bonding. Complex 1 and 2 were further examined for antibacterial and antiproliferative activity. Complex 1 exhibited remarkable anticancer activity whereas complex 2 has comparatively lesser anticancer potential

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