• Ritu Sharma

      Articles written in Journal of Chemical Sciences

    • Synthesis of new series of N-3-[-{2-(substituted phenyl-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine}-carbamyl]-propyl-2-aminothiazole and their biological importance

      Pushkal Samadhiya Ritu Sharma Santosh K Srivastava Savitri D Srivastava

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      Synthesis of new series of N-3-[-{2-(substituted phenyl-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine}-carbamyl]-propyl-2-aminothiazole, 5(a-s) have been developed. The cycloaddition reaction of thioglycolic acid with N-{3-(substituted benzylidine-carbamyl)-propyl}-2-aminothiazole, 3(a-s) in the presence of anhydrous ZnCl2 afforded new heterocyclic compounds N1-3-[-{2-(substituted phenyl-4-oxo-1,3-thiazolidine}-carbamyl]-propyl-2-aminothiazole 4(a-s). The latter product on treatment with several selected substituted aromatic aldehydes in the presence of C2H5ONa undergoes Knoevenagel reaction to yield 5(a-s). The structure of compounds 1, 2, 3(a-s), 4(a-s) and 5(a-s) were confirmed by IR, 1H NMR, 13C NMR, FAB mass and chemical analysis. All final compounds were screened for their antimicrobial activity against some selected bacteria and fungi and antituberculosis study against M. tuberculosis, gave acceptable activity.

    • Synthesis and pharmaceutical importance of 2-azetidinone derivatives of phenothiazine

      Ritu Sharma Pushkal Samadhiya S D Srivastava S K Srivastava

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      A new series of 𝑁-[3-(10𝐻-phenothiazin-1-yl)propyl]-4-(substituted phenyl)-3-chloro-2-oxo-1-azetidinecarboxamide 4(a-m) have been synthesized from phenothiazine in four steps. Phenothiazine on reaction with Cl(CH2)3Br at room temperature gave 1-(3-chlorophenyl)-10𝐻-phenothiazine, 1. The compound 1 yielded the condensation product with urea at room temperature, 𝑁-[3-(10𝐻-phenothiazin-1-yl)propyl]urea 2. The compound 2 on further reaction with several substituted aromatic aldehydes produced 𝑁-[3-(10𝐻-phenothiazin-1-yl)propyl]-$N'$-[(substituted phenyl)methylidene]-urea 3(a-m). The compounds 3(a-m) on treatment with ClCH2COCl in the presence of Et3N furnished final products 4(a-m). The structures of all the newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and FAB-Mass spectra and chemical methods. All the final synthesized compounds were evaluated for their antibacterial, antifungal and antitubercular activities which displayed acceptable activities.

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