• Ravindra R Kamble

Articles written in Journal of Chemical Sciences

• Synthesis, spectral characterization and antihaemostatic activity of 1,2,4-triazoles incorporating 1,2,4-triazine rings

A simple and high yielding method for the integration of a 1,2,4-triazole ring with 1,2,4-triazine-5-one (4a-j) has been developed starting from 3-arylsydnones (1a-d). The structures were proved by their spectral data and screened for antihaemostatic activity.

• An efficient synthesis, X-ray and spectral characterization of biphenyl derivatives

Derivatives of 1,3-thiazolidin-2,4-dione appended to biphenyl ring viz., 7-9, 16-18 were prepared. The newly synthesized compounds were confirmed by IR, NMR (1H and 13C) MS and elemental analyses. Single crystal X-ray diffraction study was carried out for one of the final compounds 9.

• An expeditious green synthesis of Schiff bases and azetidinones derivatised with 1,2,4-triazoles

An efficient green approach to the synthesis of Schiff bases (11-21) of 1-amino-2-aryl-3-oxo-1,2,4-triazoles (1-3) have been reported under Mg(ClO4)2 as catalyst followed by the reaction with chloroacetyl chloride in solvent-free conditions to yield the azetidinones (22-32) with excellent yields. The synthesized compounds were evaluated for the extent of penetration into biological membranes ($clogP$), drug-likeliness and finally drug score was calculated and also screened for antitubercular and antimicrobial activities.

• # Journal of Chemical Sciences

Volume 134, 2022
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Continuous Article Publishing mode

• # Editorial Note on Continuous Article Publication

Posted on July 25, 2019