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- Ramachandran Azhakar
  
  Articles written in Journal of Chemical Sciences
- Volume 117 Issue 2 March 2005 pp 175-178
  
  Biocatalysis by metallated cyclotriphosphazenes: L₂Zn(NO₃)₂ {L = spiro-N₃P₃[O₂C₁₂H₈][N(CH₃)NH₂]} as a synthetic phosphoesterase and nuclease
  
  Vadapalli Chandrasekhar Venkatasubbiah Krishnan Ramachandran Azhakar C Madhavaiah Sandeep Verma
  
  More Details Abstract Fulltext PDF
  
  Catalytic activity of [L₂.Zn][NO₃]₂] (L = spiro-N₃P₃[O₂C₁₂H₈][N(CH₃)NH₂]) towards the hydrolysis of two phosphodiesters, [bis(p-nitrophenyl)phosphate, bNPP] and [2-(hydroxypropyl)-p-nitrophenyl phosphate, hNPP] has been examined. While the rate of hydrolysis of the former is accelerated over a million-fold, the rate of hydrolysis of the latter also is enhanced considerably. Detailed kinetic evaluation of these reactions has been carried out and all the kinetic parameters including the Michaelis-Menten parameters are reported. The catalyst [L₂.Zn][NO₃]₂] has also been found to be an effective nuclease. Relaxation of supercoiled plasmid DNA, pBR322, occurs in presence of [L₂.Zn][NO₃]₂ without the need for any exogenous reagents.

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