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Microwave-assisted synthesis of some new 1,2,3-triazole derivatives and their antimicrobial activity
A series of new 1,2,3-triazole derivatives were designed and synthesised through Cu(I) catalysed 1,3-dipolar cycloaddition of alkynes and organic azides namely click reaction, under both conventional and microwave irradiation methods. Higher yields were achieved in lesser time under microwave irradiationmethod by using CuI as the catalyst. Herein, the two triazole moieties are linked through the O-alkoxy oxime linkage. All the synthesised molecular structures are elucidated by 1H-NMR, 13C-NMR, IR and mass spectral analysis and screened for their
in vitro antimicrobial activity. -
A new series of 2,4,6-triarylpyridines are synthesised through one-pot three-component condensation of triazole pyrazolyl aldehydes and acetophenones with ammonium acetate in moderate to good yields. The structures of the synthesised compounds are confirmed by spectral methods viz. IR, 1H NMR, 13C NMR and mass spectral analysis. All these scaffolds are evaluated for their in vitro antimicrobial activity and found to exhibit promising antimicrobial potency.
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Journal of Chemical Sciences
Volume 135, 2023
All articles
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