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A review on transition-metal mediated synthesis of quinolines
Quinoline is one of the important class of heterocyclic compounds which have gained considerable importance because of its high pharmaceutical efficacy and broad range of biological activities such as anticancer, anti-malarial, anti-microbial and anti-asthmatic. As a consequence, the desire for new versatile andefficient route for the synthesis of quinoline scaffolds remains an active and growing area of interest both in academia and industry. However, developments of transition-metal catalyzed synthetic methods have witnessed a dominant position over the past few years for the synthesis of diverse range of complex heterocyclics containing quinoline scaffolds. This review specifically provides an overview of the literature available on the transition–metal catalyzed synthetic methodologies for the synthesis of polysubstituted quinoline derivatives.
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A simple, efficacious, and regioselective synthesis of hitherto unreported benzotriazole-triazole conjugates
via copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction between benzotriazole alkynes and aryl azides has been described. The structure of the synthesized molecules has been explicitly confirmed by spectroscopic analysis (1H NMR, 13C NMR, and mass spectroscopy).This work describes a very simple, efficacious, and regioselective synthesis of hitherto unreported benzotriazole-triazole conjugates
via copper-catalyzed azide-alkyne cycloaddition. The current protocol avoids the use of any reducing agent, which makes this protocol a better route for the synthesis of 1,4-disubstituted product.
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Journal of Chemical Sciences
Volume 135, 2023
All articles
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