Articles written in Journal of Chemical Sciences
Volume 129 Issue 10 October 2017 pp 1549-1557 REGULAR ARTICLE
An expedient synthesis of coumarin-pyridone conjugate molecules 2a-o is reported via one-pot reaction between (E)-3-(3-arylacryloyl)-2H-chromen-2-ones 1a-o, ethyl 2-nitroacetate and ammonium acetate. The structures of synthesized compounds have been unambiguously confirmed by spectroscopic analyses (NMR, IR and MS). All the compounds were screened for their anti-microbial activities against three Gram-positive bacterial strains, two Gram-negative bacterial strains and four fungal organisms. Compounds 2d, 2i, 2k, 2oexhibited mild anti-bacterial activity and 2d, 2m were found to be moderately active against all the tested fungal organisms. Compound 2k showed good inhibitory potential against the tested yeasts organisms.
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