Abstract. Two new series of compounds (Z/E)-2-phenyl/H-3-Styryl-2H-Chromenes 9(a-r) and 10(a-s)were synthesized and evaluated in vitro cytotoxic activities against four cancer cell lines. One compound, Z)-8-ethoxy3-(4-methoxystyryl)-2-phenyl-2H-chromene (9g) was found to be the most active among the tested compounds in HeLa cell lines (IC5010μM). Compound 9g arrested cells at G2/M phase, disrupted microtubule network, accumulated tubulin in the soluble fraction and manifested an increased expression of the G2/M marker, Cyclin B1
