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Use of convertible isocyanides for the synthesis of benazepril hydrochloride
Herein, we have described a novel and concise synthesis of the potent angiotensin-convertingenzyme (ACE) inhibitor, benazepril hydrochloride (7) in trifluoroethanol
via an Ugi three-component reactionin shorter reaction times. The key step is the trifluoroacetic acid-mediated hydrolysis of secondary amides (4aand 4b) followed by esterification as a domino process to form corresponding ethyl ester (6). Mainly twouniversal convertible isocyanides (1a and 1b) were used for the synthesis of benazepril hydrochloride.Synopsis: An efficient synthesis of benazepril hydrochloride using Ugi three-component reaction.
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Journal of Chemical Sciences
Volume 135, 2023
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