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Journal of Chemical Sciences
Volume 135, 2023
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POMBALA SUJITHA
Articles written in Journal of Chemical Sciences
Volume 128 Issue 6 June 2016 pp 929-939 Regular Article
PONNAPALLI VEERABHADRA SWAMY PULLAIAH CHINA KAMBHAMPATI KOTHAPALLI BONNOTH CHANDRASEKHAR GUGULOTHU THIRUPATHI POMBALA SUJITHA CHITYAL GANESH KUMAR VEERAMACHANENI GANESH KUMAR
The synthesis of novel series of cyclopropane carbohydrazides is described via Knoevenagel condensationof 2-furfuraldehyde with malonic acid in five steps. Condensation of the key intermediate 2-(furan-2-yl)cyclopropanecarbohydrazide (4) with heteroaryl/aryl aldehydes (a-t) in presence of ZnO NP in ethanolresulted in substituted N- hetero/arylidene-2-(furan-2-yl) cyclopropane carbohydrazides (5a-t). These compoundswere screened for their anticancer activity against a panel of four cancer cell lines and four compoundsshowed promising activity at micromolar concentration against all the tested cell lines with IC50 values rangingbetween 1.9-8.45μM. These compounds were further validated with in silico methods at the anticancer target,colchicine binding site.
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