PANKAJ R CHAUDHARI
Articles written in Journal of Chemical Sciences
Volume 134 All articles Published: 20 April 2022 Article ID 0056
The given article describes the synthesis of 2-Oxazolidinone ring
Selective α-aminoxylation was achieved on corresponding aldehyde with great enantiomeric excess to get intermediate (5) using catalytic amount of low cost proline. The oxazolidinone ring was then constructed on common intermediate (5) which was then further converted to Oxazolidinone class compounds like Sutezolid and Eperezolid.
Volume 135 All articles Published: 24 June 2023 Article ID 0067
Given article describes the synthesis of 5-HT1 agonist rizatriptan via the construction of anindole ring on 3-Methyl-4-nitrobenzoic acid methyl ester by Leimgruber-Batcho reaction. The indole intermediate obtained is then further converted to rizatriptan, a triptan-class compound. Using simple, facile and an efficient methodology, rizatriptan was prepared.
The construction of the indole ring was carried out on 3-methyl-4-nitrobenzoic acid methyl ester. The indole intermediate obtained was then treated with Oxalyl chloride to get an oxoacetyl indole carboxylate intermediate. The Intermediate obtained was then further converted to rizatriptan.
Volume 135, 2023
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